The rates are based on adverse reactions considered probably drug related by the investigator.
Labetalol HCl USP tablets are adrenergic receptor blocking agents that have both selective alpha 1-adrenergic and non-selective beta-adrenergic receptor blocking actions in a single substance.. Labetalol HCl USP is a racemate, chemically designated as 5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl] salicylamide monohydrochloride, and it has the following … During controlled hypotensive anesthesia using Labetalol in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure.
The desired blood pressure lowering should therefore be achieved over as long a period of time as is compatible with the patient’s status.Labetalol HCI injection should be used with caution in patients with impaired hepatic function since metabolism of the drug may be diminished.Symptomatic postural hypotension (incidence, 58%) is likely to occur if patients are tilted or allowed to assume the upright position within 3 hours of receiving Labetalol HCl injection. Studies with Labetalol using dominant lethal assays in rats and mice and exposing microorganisms according to modified Ames tests showed no evidence of mutagenesis.Teratogenic studies were performed with Labetalol in rats and rabbits at oral doses up to approximately six and four times the maximum recommended human dose (MRHD), respectively. Increased fetal resorptions were seen in both species at doses approximating the MRHD.
Neither hemodialysis nor peritoneal dialysis removes a significant amount of Labetalol from the general circulation (<1%).Labetalol HCl Injection, USP is indicated for control of blood pressure in severe hypertension.Labetalol HCl injection is contraindicated in bronchial asthma, overt cardiac failure, greater-than-first-degree heart block, cardiogenic shock, severe bradycardia, other conditions associated with severe and prolonged hypotension, and in patients with a history of hypersensitivity to any component of the product (see Beta-blockers, even those with apparent cardioselectivity, should not be used in patients with a history of obstructive airway disease, including asthma.Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with Labetalol therapy.
Labetalol systemic 100 mg (100 WARRICK 1602) Beta Blocker Heart Meds Might Pose Special Risks for Women Labetalol is approximately 50% protein bound.
The effect of Labetalol’s alpha adrenergic activity has not been evaluated in this setting.Several deaths have occurred when Labetalol HCl injection was used during surgery (including when used in cases to control bleeding).A synergism between Labetalol and halothane anesthesia has been shown (see Caution must be observed when reducing severely elevated blood pressure. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.The presence of Labetalol metabolites in the urine may result in falsely elevated levels of urinary catecholamines, metanephrine, normetanephrine, and vanillylmandelic acid (VMA) when measured by fluorimetric or photometric methods. The contribution of each of the treatments to this adverse reaction is unknown, but the possibility of a drug interaction cannot be excluded.Drugs possessing beta-blocking properties can blunt the bronchodilator effect of beta-receptor agonist drugs in patients with bronchospasm; therefore, doses greater than the normal antiasthmatic dose of beta-agonist bronchodilator drugs may be required.Cimetidine has been shown to increase the bioavailability of Labetalol administered orally. However, following abrupt cessation of therapy with some beta-blocking agents in patients with coronary artery disease, exacerbations of angina pectoris and, in some cases, myocardial infarction have been reported. If cardiac failure continues despite adequate digitalization and diuretic, Labetalol therapy should be withdrawn (gradually, if possible).Angina pectoris has not been reported upon Labetalol discontinuation. Laboratory testing should be done at the very first symptom or sign of liver dysfunction (e.g., pruritus, dark urine, persistent anorexia, jaundice, right upper quadrant tenderness, or unexplained “flu-like” symptoms).
If overdosage with Labetalol HCl follows oral ingestion, gastric lavage or pharmacologically induced emesis (using syrup of ipecac) may be useful for removal of the drug shortly after ingestion. One of these patients developed hypotension following Labetalol treatment. Therefore, these drugs should not be administered in the same infusion line.While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic.
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