<< /Type /Outlines /Count 0 >> "Product Information.
>> The study of the drug Lamictal made it possible to note the pregnancy results of about 2000 women who received lamotrigine as monotherapy during the first trimester of pregnancy. 5 0 obj Pregnancy is a vulnerable period for recurrence of bipolar disorder.
Kindling is described as the clinical development of bipolar disorder from reactive and triggered symptoms to a more frequent, severe and spontaneously occurring form.Although lamotrigine is commonly prescribed and has a good safety profile, a study in 2008 in the Neurology journal reported that lamotrigine exposure increased the frequency of congenital anomalies such as cleft palate in babiesTo further test this, a new study by Dolk and colleagues aimed to determine the discrepancies in the literature by investigating the association between orofacial clefts and lamotrigine exposure during pregnancy.
While there is not enough data to answer these questions conclusively, researchers have been able to gather enough information to issue guidelines. Lamotrigine, in psychiatry, is used in the treatment of bipolar disorder.Lamotrigine has multiple mechanisms of action, which give this drug its diverse anti-seizure properties as well as its novel thymoleptic and psychotropic properties.Research shows that lamotrigine’s clinical profile is the result of distinct and overlapping mechanisms that contribute to each of its pharmacological actions. Pooled analysis of other pregnancy registries report the rate of isolated oral clefts with monotherapy at 4 in 2226 (prevalence rate: 1.79/1000); a prevalence rate at the upper end of the general population.
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Lamictal does pass into breast milk, and the prescribing information says breastfeeding while taking Lamictal or lamotrigine (in any form) is not recommended.
Proconvulsant activity is linked to Na+ influx through voltage-gated Na+ channels, which inturn leads to glutamate excitotoxicity.Lamotrigine blocks voltage-gated Na+ channels inhibiting glutamate excitotoxicity.Lamotrigine also enhances the release of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that attenuates neuronal electrical activity associated with paroxysms.Lamotrigine is approved for the management of bipolar I disorder due to its stabilising effect on depressive symptoms.
Maternal toxicity was observed at the 2 highest doses. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect.
The authors found no strong independent evidence of a risk of clubfoot subsequent to their original signal. 4 0 obj To further test this, a new study by Dolk and colleagues aimed to determine the discrepancies in the literature by investigating the association between orofacial clefts and lamotrigine exposure during pregnancy. Lamotrigine is an anti-epileptic drug that has been approved for the maintenance treatment of bipolar disorder. /Parent 3 0 R Thus far, Lamictal has not been shown to cause any significant increases in birth defects overall.The FDA-approved prescribing information says that lamotrigine "should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus."
Is it, or the generic lamotrigine, safe during breastfeeding? /Length 1779 >> The safety of using Lamictal during pregnancy has not been established.
The lowest effect dose for peri/postnatal developmental toxicity was less than the human dose of 400 mg/day on mg/m2 basis. It is mainly during this time that some medicines are known to cause birth defects. /F4 16 0 R Pregnant rats administered 3 doses (5, 10 or 20 mg/kg) during the latter part of gestation had increased offspring mortality (including stillbirths) at all doses.
We comply with the HONcode standard for trustworthy health information - �;�-�=Lv'�m�Մ����LG���m����ԣTǺ�vn�Zٝ�$��^2�hU�b� ��C��v;7Q���q�J ���L(Ե��ט����������ԯz�R�:87G^�Y��V�u�ڔm7"�C:�֚=A���z@yS#�ՠMi� ���t15`�L�B�)T��Hb���X+��ٹp��6��C@�DD�����+��BZ�ҽ�wa-�6 A�w ;�[���>��G"�����#%I&����8I��ǒ�}H(ވ�+����I�f�Qw���7]�����۷�����G^f�y���~��Ub�c�̫ o? Whenever possible, monotherapy is preferred, as multiple AEDs could be associated with a higher risk of congenital malformations depending on the associated antiepileptics.
If an adverse event occurs, a serum level can be measured to rule out toxicity. For a baby’s growth and development in the womb folic acid is necessary.
7 0 obj Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0. Lamictal should be used during pregnancy only if clearly needed.
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