Lancet Oncol. 2020 Sep;80(13):1345-1353. doi: 10.1007/s40265-020-01374-0. 2020 May;21(5):605-607. doi: 10.1016/S1470-2045(20)30097-8. Epub 2020 Mar 27.Calvo E, Moreno V, Flynn M, Holgado E, Olmedo ME, Lopez Criado MP, Kahatt C, Lopez-Vilariño JA, Siguero M, Fernandez-Teruel C, Cullell-Young M, Soto Matos-Pita A, Forster M.Ann Oncol. Per investigator assessment, overall response was achieved by 37 patients (35.2%; 95% confidence interval [CI], 26.2% to 45.2%).
All patients were treated only with one prior line of chemotherapy at least three weeks prior to the start of the study. In this phase 2 study, we evaluated the acti and safety of lurbinectedin in patients with SCLC after failure of platinum-based chemotherapy. Every three weeks, patients received 3.2 mg/mFinal analysis included 105 lurbinectedin-treated patients who were followed for a median 17.1 months. Efficacy of Zepzelca (lurbinectedin) in adult patients with metastatic SCLC with disease progression Last checked Jul 20, 2020. Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study. 2020 Feb;126:21-32. doi: 10.1016/j.ejca.2019.10.021. Please enable it to take advantage of the complete set of features!
Manuscripts must be solely the work of the author(s) stated, must not have been previously published elsewhere, and must not be under consideration by another journal. Unable to load your delegates due to an error This site needs JavaScript to work properly. Eleven patients (10%) presented serious treatment-related AEs, primarily neutropenia (5%) febrile neutropenia (5%). Elsevier Science Hematological abnormalities were the most commonly cited grade 3 to 4 adverse events (AEs), in particular anemia (9%), leucopenia (29%), neutropenia (46%), and thrombocytopenia (7%). Lurbinectedin was added to the Clinical Practice Guidelines in Oncology by the National Comprehensive Cancer Network on July 7, 2020 for the treatment of patients with small cell lung cancer. Susan M Domchek, Sophie Postel-Vinay, Seock-Ah Im, Yeon Hee Park, Jean-Pierre Delord, Antoine Italiano, Lurbinectedin may be a viable option as a second-line treatment for small-cell lung cancer (SCLC) patients whose first-line therapy was unsuccessful, a study found.The trial included adult patients from 26 hospitals in the U.S. and six countries in Europe with a pathologically proven SCLC diagnosis. doi: 10.1016/S1470-2045(20)30068-1. The FDA approval of this drug is based on monotherapy clinical data from an openlabel, multi-center, single-arm study in 105 adult platinum-sensitive and platinum-resistant patients with relapsed SCLC 1.The data, which appeared in The Lancet Oncology, in the May 2020 issue, showed that in relapsed SCLC, lurbinectedin demonstrated an ORR of 35 percent and a median DoR of 5.3 months as … Lurbinectedin is a selective inhibitor of oncogenic transcription. Elsevier Science 2016 Jul;17(7):883-895. doi: 10.1016/S1470-2045(16)30098-5. Lurbinectedin may be a viable option as a second-line treatment for small-cell lung cancer (SCLC) patients whose first-line therapy was unsuccessful, a study found. 4. Clipboard, Search History, and several other advanced features are temporarily unavailable. Unable to load your collection due to an error In a new Commission from The Lancet Oncology, Stein Kaasa and colleagues critically discuss how to integrate oncology and palliative care using standardised care pathways, referral guidelines, and collaboration to achieve the best outcomes for patient-centred care.
Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial Trigo, J., The Lancet Oncology, Mar 27, 2020 Epub 2016 Jun 14.Antonia SJ, López-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, Jäger D, Pietanza MC, Le DT, de Braud F, Morse MA, Ascierto PA, Horn L, Amin A, Pillai RN, Evans J, Chau I, Bono P, Atmaca A, Sharma P, Harbison CT, Lin CS, Christensen O, Calvo E.Lancet Oncol. There were no treatment-related deaths.“Lurbinectedin was active as second-line therapy for Lurbinectedin Successful Second-line Treatment for Small-cell Lung Cancer Patients After First-line Failure
“Few options exist for treatment of patients with small-cell lung cancer (SCLC) after failure of first-line therapy. 2017 Oct 1;28(10):2559-2566. doi: 10.1093/annonc/mdx357.Goto K, Ohe Y, Shibata T, Seto T, Takahashi T, Nakagawa K, Tanaka H, Takeda K, Nishio M, Mori K, Satouchi M, Hida T, Yoshimura N, Kozuki T, Imamura F, Kiura K, Okamoto H, Sawa T, Tamura T; JCOG0605 investigators.Lancet Oncol. Epub 2016 Jun 4.Cote GM, Choy E, Chen T, Marino-Enriquez A, Morgan J, Merriam P, Thornton K, Wagner AJ, Nathenson MJ, Demetri G, George S.Eur J Cancer. Eligibility criteria included Eastern Cooperative Oncology Group performance status of 2 or lower, measurable disease using the Response Criteria in Solid Tumors (RECIST) version 1.1, no brain metastasis, and adequate organ function.
Epub 2019 Dec 31.Drugs. 2016 Aug;17(8):1147-1157. doi: 10.1016/S1470-2045(16)30104-8.
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