Maximum dose: 600 mg/dose.
Patients received 600 mg bid iv or po linezolid. Six days after surgery, 2 cultures of femur tissue yielded The patient was treated with the recommended oral dosage of linezolid, 600 mg q12h for a total of 8 weeks. Despite similarities in age and renal function, the first patient experienced an elevated trough concentration. Doubts and certainties.Results of treating patients with significant, resistant, Gram positive, intra‐abdominal infections with linezolid [abstract].Linezolid versus vancomycin for the treatment of MRSA infections: results of a randomized phase III trial [abstract].9th International Congress on Infectious Diseases, Buenos Aires, 10–13 April 2000Comparison of length of hospital stay for patients with known or suspected methicillin‐resistant Linezolid use in patients who are intolerant to or fail vancomycin [abstract].Compassionate linezolid treatment of severe methicillin‐resistant Linezolid in the treatment of vancomycin‐resistant enterococcus: a dose comparative, multicenter phase III trial [abstract].Outcomes of linezolid in patients with malignancies and significant Gram‐positive infections [abstract].Results of treating bone marrow transplant patients with linezolid in a compassionate use protocol for Gram‐positive infections [abstract].Use of linezolid, an oxazolidinone, in the treatment of multidrug‐resistant Gram‐positive bacterial infections.Successful treatment of persistent vancomycin‐resistant Linezolid (PNU‐100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double‐blind, multicenter study.Efficacy of linezolid in Gram‐positive infections: results from two phase II trials [abstract].Linezolid in the treatment of community‐acquired pneumonia: the results of phase II and phase III studies [abstract].9th International Congress on Infectious Diseases, Buenos Aires, 10–13 April 2000:Comparison of linezolid versus ceftriaxone/cefpodoxime in the treatment of hospitalized patients with community‐acquired pneumonia.Oral linezolid in the treatment of community‐acquired pneumonia: a phase III trial.Linezolid versus cephalosporin therapy in the treatment of patients with community‐acquired pneumonia: summary of two randomized trials.Linezolid is superior to cephalosporins in treatment of patients with bacteremic Linezolid for the treatment of pneumonia in hospitalized children: an open‐label, subgke‐arm, multicenter study [abstract].9th International Congress on Infectious Diseases, Buenos Aires, 10–13 April 2000:Randomized comparison of linezolid (PNU‐100766) versus oxacillin‐dicloxacillin for treatment of complicated skin and soft tissue infections.Comparison of oral linezolid to oral clarithromycin in the treatment of uncomplicated skin infections: results from a multinational phase III trial [abstract].9th International Congress on Infectious Diseases, Buenos Aires, 10–13 April 2000:Comparison of linezolid and flucloxacillin in the treatment of complicate skin infections: analysis of European and South African patients in a regional phase III trial [poster A].Third International Meeting on the Therapy of Infections, Florence, December 2000Successful treatment of vertebral osteomyelitis with linezolid in a patient receiving hemodialysis and with persistent methicillin‐resistant Identification of a novel oxazolidinone (U‐100480) with potent antimycobacterial activity.Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.Safety and tolerance of linezolid in phase II trials [abstract].39th ICAAC, 26–29 September 1999, San Francisco, CA:Program and Abstract of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, 2000The oxazolidinones as a new family of antimicrobial agent, Simple method for the assay of linezolid in Brain Heart Infusion broth by high‐performance liquid chromatography,
The patient then fractured his proximal femur at the tip of the prosthesis. The fracture was repaired with a cable and plate fixation system that subsequently failed, and a second procedure was performed to stabilize the fracture.
Simultaneous Y‐site administration of linezolid injection with one of the five drugs resulting in physical incompatibilities should be avoided [Oral linezolid may be taken with small quantities of food or without food, but a high‐fat meal decreases the maximum plasma concentration by about 17%. The in vivo activity of linezolid or cefazolin against a clinical isolate of methicillin-susceptible Staphylococcus aureus (linezolid MIC, 2 μg/ml) was studied in a rat model of experimental osteomyelitis.
89 patients were enrolled into the compassionate use program with the diagnosis of osteomyelitis and were evaluated for clinical efficacy, safety and tolerability.
Pulmonary disease is associated with human T-cell leukaemia virus type 1c infection: a cross-sectional survey in remote Aboriginal Australian communities. For the second case, once drug exposure was increased, he rapidly improved and was extubated within 48 hours of the dosing modifications.
You can also search for this author in Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. The mainstream thinking that only specific kinds of patients (ie, elderly, renal or hepatic failure, etc) need TDM, but this is not always true. Duration of therapy: -Pneumonia: 10 to 14 consecutive days.
Although this strategy provides evidence for achieving minimal effectiveness; it does not result in 100% cure, nor does it prevent toxicity.
Staphylococcus aureus is the most frequent cause of osteomyelitis, accounting for >50% of … and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username
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