Side effects are NOT tested pre and post.
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Some of them (lumiracoxib, rimonabant, tolrestat, ximelagatran and ximelidine, for example) were approved to be marketed in Europe but had not yet been approved for marketing in the US, when side effects became clear and their developers pulled them from the market.
For drug candidates that were abandoned prior to being marketed due to side effects, lack of efficacy, superior competitors, or other reasons, see Category:Abandoned drugs.
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That is just what happened with Avastin and breast cancer.Viewed by many metastatic breast cancer patients as a last hope, the FDA approved Avastin for breast cancer in 2008 on what's known as an 'accelerated-approval basis,' where a company must present to the FDA more evidence of a drug's efficacy after approval--or face a recall.
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