It will
400 mcg of nitroglycerin after an initial priming of five sprays. Treatment of nitroglycerin overdose in these patients may be subtle and difficult, and invasive monitoring may be required. varying conditions, adverse reaction rates observed in the clinical trials of a
To prime your Nitrolingual Pumpspray, follow the steps
Increasing salivation with chewing gum or artificial saliva products may prove useful in aiding dissolution of sublingual nitroglycerin. Do
If the pain persists after a total of 3 tablets in a 15-minute period, or if the pain is different than is typically experienced, seek prompt medical attention.Nitroglycerin Sublingual Tablets may be used prophylactically 5 minutes to 10 minutes prior to engaging in activities that might precipitate an acute attack.For patients with xerostomia, a small sip of water prior to placing the tablet under the tongue may help maintain mucosal hydration and aid dissolution of the tablet.Administer Nitroglycerin Sublingual Tablets at rest, preferably in the sitting position.Nitroglycerin Sublingual Tablets, USP are supplied as white, round, flat-faced tablets in three strengths:Do not use Nitroglycerin Sublingual Tablets in patients who are taking PDE-5 Inhibitors, such as avanafil, sildenafil, tadalafil, vardenafil hydrochloride. The total number of available doses is
Heart rate is usually slightly increased, presumably due to a compensatory response to the fall in blood pressure. Mechanism of Action. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Nitrate overdosage may result in: severe hypotension, persistent throbbing headache, vertigo, palpitation, visual disturbance, flushing and perspiring skin (later becoming cold and cyanotic), nausea and vomiting (possibly with colic and even bloody diarrhea), syncope (especially in the upright posture), methemoglobinemia with cyanosis and anorexia, initial hyperpnea, dyspnea and slow breathing, slow pulse (dicrotic and intermittent), heart block, increased intracranial pressure with cerebral symptoms of confusion and moderate fever, paralysis and coma followed by clonic convulsions, and possibly death due to circulatory collapse.Case reports of clinically significant methemoglobinemia are rare at conventional doses of organic nitrates. deliver intended dose.Lingual spray, 400 mcg per spray available in either 60
Jacksonville, FL 32250 by G. Pohl-Boskamp GmbH & Co. KG, 25551
If the pain persists after a total of 3 tablets in a 15-minute period, or if the pain is different than is typically experienced, prompt medical attention is recommended. orientation for administration at night [see The amount of liquid remaining in the container should be
included: headache, dizziness, and The following adverse reactions have been identified
1985; 56: 484-485. The high dose was associated with decreased feed intake and body weight gain in both sexes at all matings. uncertain size, it is not always possible to estimate their frequency reliably
Rats developed dose-related fibrotic and neoplastic changes in liver, including carcinomas, and interstitial cell tumors in testes. Effective coronary perfusion pressure is usually maintained, but can be compromised if blood pressure falls excessively, or increased heart rate decreases diastolic filling time. Better blood flow means your heart doesn't have to work as hard.
Therefore, patients receiving sublingual nitroglycerin should avoid ergotamine and related drugs or be monitored for symptoms of ergotism if this is not possible. This drug should therefore be used with caution in patients who may be volume-depleted or who, for whatever reason, are already hypotensive. ST-segment depression were seen following doses of 0.2, 0.4, 0.8 and 1.6 mg of
No more than three tablets are recommended within a 15-minute period. Do not give Nitroglycerin Sublingual Tablets to other people, even if they have the same symptoms you have. Angina feels like a pressing or squeezing pain, usually in your chest under the breastbone. Nitroglycerin sublingual tablets are contraindicated in patients who are allergic to it. miscarriage in clinically recognized pregnancies is 2 – 4% and 15 – 20%,
There may be new information. usually subside with continued use.Advise the patient to read the FDA-approved patient
during post-approval use of Nitrolingual Pumpspray and other nitroglycerin
Am J Cardiol.
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