Wilcox CM, Darouiche RO, Laine L et al. 45. Dismukes WE, Bradsher RW, Cloud GC et al. 88. Penicillium marneffei: types and drug susceptibility. Hepatic injury associated with itraconazole. Panel on Clinical Practices for Treatment of HIV Infection of the Department of Health and Human Services (DHHS). 5. Sharkey PK, Rinaldi MG, Dunn JF et al. Pappas PG, Kauffman CA, Andes D et al. Indicated for onychomycosis of the toenail or fingernail owing to dermatophytes (tinea unguium250 mg (1 tablet) PO daily for 6 weeks (fingernail) or 12 weeks (toenail)Renal impairment: Use not recommended if CrCl <50 mL/minHepatic impairment: Use contraindicated in chronic or active liver disease250 mg/day PO in single dose or divided q12hr for 2-6 weeks250 mg/day PO in single dose or divided q12hr for 2-4 weeks500 mg/day PO q12hr for 2-6 weeks; treat for additional 2-4 weeks after resolution of all lesions (resolution may take 3-6 months)Idiosyncratic and symptomatic hepatic injury; more rarely, cases of liver failure, some leading to death or liver transplantSkin and subcutaneous tissue disorders (eg, Stevens-Johnson Syndrome and toxic epidermal necrolysis), drug reaction with eosinophilia and systemic symptoms (DRESS) syndromeSevere neutropenia, thrombocytopenia, agranulocytosis, pancytopenia, anemiaPsoriasiform eruptions or exacerbation of psoriasis, acute generalized exanthematous pustulosis, precipitation and exacerbation of cutaneous and systemic lupus erythematosusMalaise, fatigue, vomiting, arthralgia, myalgia, rhabdomyolysis, reduced visual acuity, visual field defect, hair loss, serum sickness-like reaction, vasculitis, pancreatitis, influenzalike illness, pyrexia, increased blood creatine phosphokinase, photosensitivity reactionsThrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndromeDiscontinue if the following develop: Liver disease, neutropenia (absolute neutrophil count <1000 mcL); skin rash; signs or symptoms of SLEChanges in ocular lens and retina reported; may require discontinuation of therapyPeriodic monitoring of liver function tests is recommendedAsk patients and caregivers to report immediately to healthcare provider any symptoms or signs of persistent nausea, anorexia, fatigue, vomiting, right upper abdominal pain or jaundice, dark urine, or pale stools; if these symptoms occur discontinue taking oral terbinafine, and immediately evaluate patient’s liver functionSerious skin/hypersensitivity reactions (eg, Stevens-Johnson Syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome); manifestations of DRESS syndrome may include cutaneous reaction (eg, rash, exfoliative dermatitis), eosinophilia, and 1 or more organ complications (eg, hepatitis, pneumonitis, nephritis, myocarditis, pericarditis)Due to potential toxicity, confirmation of onychomycosis or dermatomycosis recommendedSmell disturbance reported; discontinue therapy if symptoms occurCYP2D6 inhibitor; may also convert CYP2D6 extensive metabolizers to poor metabolizer statusCases of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, some fatal, reported with terbinafine; discontinue terbinafine if clinical symptoms and laboratory findings consistent with TMA occur; the findings of unexplained thrombocytopenia and anemia should prompt further evaluation and consideration of diagnosis of TMAAvailable data from postmarketing cases in pregnant women are insufficient to evaluate drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomesBecause treatment of onychomycosis can be postponed until after pregnancy is completed, it is recommended that oral terbinafine not be initiated during pregnancyAfter oral administration, terbinafine is present in human milk; however, there are no data on effects on breastfed child or on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy; tablets and any potential adverse effects on breastfed child from therapy or from underlying maternal conditionA: Generally acceptable.
Cerebral blastomycoma after ketoconazole therapy for respiratory tract blastomycosis. Wayne, PA: NCCLS; 1997 Jun.78. Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. Diseases & Conditions Diseases & Conditions 92. Fromtling RA. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America.
95. 123. Grant SM, Clissold SP. Wheat J, Hafner R, Korzun AH et al. 11. Chao D, Steier KJ, Gomila R. Update and review of blastomycosis. Drugs Schäfer-Korting M, Korting HC, Amann F et al. Van t Wout JW, Mattie H, van Furth R. Comparison of the efficacies of amphotericin B, fluconazole, and itraconazole against a systemic 6. Galgiani JN, Ampel NM, Blair JE et al. Cleary JD, Taylor JW, Chapman SW. Itraconazole in antifungal therapy. Pasha TM, Leighton JA, Smilack JD et al. 24. 2002
National Institute of Allergy and Infectious Diseases Mycoses Study Group. Itraconazole therapy for blastomycosis and histoplasmosis. Kauffman CA. Available for Android and iOS devices. Klein NC, Cunha BA. Zavasky DM, Samowitz W, Loftus T et al. A pilot study of the discontinuation of antifungal therapy for disseminated cryptococcal disease in patients with acquired immunodeficiency syndrome, following immunologic response to antiretroviral therapy.
Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (December 1, 2009). 124. Marion Merrell Dow. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name2. 125. Dosage adjustment of fentanyl may be necessary. Lyman CA, Walsh TJ. 96. Hughes WT, Armstrong D, Bodey GP et al. 39. 2010
21. 59. 47. 980487-overview Basidiobolomycosis of the nose and face: a case report and a mini-review of unusual cases of basidiobolomycosis. Phillips P, Bryce G, Shepherd J et al.
A double-blind, randomized study comparing itraconazole pulse therapy with continuous dosing for the treatment of toe-nail onychomycosis. 71. Torsades de pointes occurring in association with terfenadine use. Denning DW, Follansbee SE, Scolaro M et al. 30. 31. Boehringer Ingelheim Pharmaceuticals. New antifungal drugs for pulmonary mycoses. 26.
Denning DW, Lee JY, Hostetler JS et al. Dear doctor letter regarding important drug warning of Hismanal75. Drugs for sexually transmitted infections. Wheat J. Histoplasmosis. Bonifaz A, Martinez-Soto E, Carrasco-Gerard E et al. Resolution of microsporidial sinusitis and keratoconjunctivitis by itraconazole treatment. Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis. Strain delineation and antifungal susceptibilities of epidemiologically related and unrelated isolates of 81. ambisome-amphotericin-b-liposomal-999576 130. 80. 41. New York: Churchill Livingstone Inc; 1995:2300-9,2316-23,2336-8,2350-1,2371,2388- 9,2413,2428-36,2714-9.61. A000 Cholera dt 01 biovar cholerae Cholera due to Vibrio cholerae 01, biovar cholerae A001 Cholera dt biovar eltor Cholera due to Vibrio cholerae 01, biovar eltor A009 Cholera uns Pappas PG. 422.
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