When used as the only oncolytic drug therapy, the initial course of CYTOXAN for patients with no hematologic deficiency usually consists of 40 to 50 mg/kg given intravenously in divided doses over a period of 2 to 5 days.
H�l��j�@��~�=��`͌d'`m�BIC��.K� �e#;��}�ͨ�BƿfG���������_��q<6�|I]?�c>_�&�}~�$�ھ���<6����������wCwL��b�4= https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvY3l0b3hhbi1jeWNsb3Bob3NwaGFtaWRlLTM0MjIxNA== Patients with compromised renal function may show some measurable changes in pharmacokinetic parameters of CYTOXAN metabolism, but there is no consistent evidence indicating a need for CYTOXAN dosage modification in patients with renal function impairment.An oral dose of 2.5 to 3 mg/kg daily for a period of 60 to 90 days is recommended. If a child has 10 Kg body weight, then the dosage for a child should be: 250 ÷ 60 X 10 = 41.7 mg.
push. Where D (desired) is the dosage the physician ordered, A (available) is the dosage strength as stated on the medication label, and Q (quantity) is the volume in which the dosage strength is available (e.g.
Diseases & Conditions Treatment beyond 90 days increases the probability of sterility. Available is heparin 10,000 units/mL. Controlled studies in pregnant women show no evidence of fetal risk.Metabolites interfere with malignant cell growth by cross-linking tumor cell DNA; drug does not have specificity for any phase of the cell cycle; also has potent immunosuppressive activityPeak plasma time: Cyclophosphamide, 1 hr; metabolites, 2-3 hrProtein bound: Cyclophosphamide, low; metabolites, >60%Metabolites: 4-hydroperoxycyclophosphamide, 4-aldophosphamidePatients should drink plenty of fluids with PO dosesPatients should empty bladder frequently to prevent hemorrhagic cystitisSometimes, mesna is used concomitantly as prophylaxis against hemorrhagic cystitisMonitor blood counts during therapy (WBC count may decrease to 2000-3000/μL without serious risk of infection)May be administered IM, intraperitoneally, intrapleurally, by IV piggy-back, or by continuous IV infusion Additive: Cisplatin/etoposide, fluorouracil, hydroxyzine, methotrexate, methotrexate/fluorouracil, mitoxantrone, ondansetronSyringe: Bleomycin, cisplatin, doxapram, doxorubicin, droperidol, furosemide, heparin, leucovorin, methotrexate, metoclopramide, mitomycin, vinblastine, vincristineY-site (partial list): Allopurinol, amifostine, bleomycin, most cephalosporins, cisplatin, diphenhydramine, doxorubicin, doxorubicin liposomal, filgrastim, fluorouracil, furosemide, gemcitabine, linezolid, lorazepam, mitomycin, morphine, paclitaxel, prochlorperazine, propofol, sodium bicarbonate, trimethoprim/sulfamethoxazole, vancomycin, vinblastine, vincristineMaximum concentration of cyclophosphamide is limited to 20 mg/mL because of solubilityIV push: Reconstitute with NS (do not use SWI, because it is hypotonic)Infusion: Reconstitute with SWI to concentration of 20 mg/mLMay dilute further with D5W, NS, lactated Ringer solution, or other compatible fluidsDoses >500 mg up to ~1 g may be administered over 20-30 minutesTo minimize bladder toxicity, increase normal fluid intake during and for 1-2 days after cyclophosphamide therapy; most adult patients will require fluid intake of at least 2 L/day; high-dose regimens should be accompanied by vigorous hydration with or without mesna therapyAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
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