Care should be taken when assessing the relative stability of polymorphic forms, as a function of temperature, from such computational experiments which explore the dissolution of nano-scale crystals. It only comes as an oral capsule.Mefenamic acid oral capsule is available as the brand-name drug Mefenamic acid is used to treat mild to moderate pain and It’s approved to treat pain in people who are least 14 years old for no longer than seven days.
Talk to your doctor or pharmacist if they’re more severe or don’t go away.Call your doctor right away if you have serious side effects. Pilot scale production and optimization Mefenamic acid, a widely used nonsteroidal anti-inflammatory and analgesic agent, is one of the active pharmaceutical ingredients that exhibit polymorphisms. This work, in essence, was performed to verify this using Mahkota Dewa (Phaleria Macrocarpa), a good source of saponin, flavanoid, polyphenol, alkaloid, and mangiferin has an extensive range of medicinal effects. The diffusivity and intermolecular interactions were determined using mean squared displacement (MSD) and radial distribution function (RDF) analysis, respectively. The insolubility in water is often referred to strong intermolecular hydrogen bonding between cellulose molecules. They can be used to evaluate approximate theories of liquids, and to provide detailed information on the structure and dynamics of model liquids at the molecular level. The radial distribution functions (RDF) between mangiferin and water signify the presence of hydrogen bonding in the extraction process.
The magnitude of difference in the solubility parameters of drug and carrier is indicative of their miscibility. The simulation results showed strong solute-solute and solute-solvent interactions, which were O1MA•••H15MA and O1EA•••H15MA. As the local structure and dynamics of the mixtures are not fully understood so far, special attention was paid to the interaction sites taking part in hydrogen bonding, their pair distribution functions and the local structure in their vicinity. Condensed-phase Optimized Molecular Potentials for Atomistic Simulation Studies (COMPASS) force field. Talk to your doctor about other drug options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. Some may be better suited for you than others. Given that the classical nucleation theory predicts a finite probability that clusters significantly larger than the critical size, in terms of number of molecules, may dissolve, building clusters containing a greater number of molecules could improve the simulated stability of the α polymorph at 50 °C and 100 °C. Optimization The diffusion layer model is almost as simple. 's [J. Chem. Dissolution through pure diffusion without any contribution from some form of convection is rare. The mangiferin yield and antioxidant activity were analysed using high performance liquid chromatography (HPLC) and 2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay method, respectively. The simulation of the binary mixture of mangiferin:water shows that strong hydrogen bonding was formed. Our website services, content, and products are for informational purposes only.
This mass transport process generally controls dissolution rates. Serious side effects and their symptoms can include the following:Mefenamic acid oral capsule may interact with other medications, herbs, or vitamins you might be taking. These findings proved the presence of hydrogen bondsthat leads to the formation of hydrogen motif in Form I of mefenamic acid during crystallization process using ethanol as a solvent. A prerequisite for drug molecules to be transported into the bulk solution is that they detach from the solid surface, and form solvated molecules.
The MSD result showed an increment in diffusivity coefficient of mangiferin with temperature. Even without mixing, density gradients caused by concentration differences or thermal effects due to the heat of solvation can lead to natural convection. All rights reserved.International Islamic University Malaysia, Malaysia, KuantanFaculty of Chemical & Natural Resources Engineering, University Malaysia Pahang, Gambang, 26300 KDepartment of Biotechnology Engineering, Kulliyyah of Engineering, International Islamic Univ(a) Mean squared displacement of water in a pure system inComparison of radial distribution functions between waterRadial distribution functions between atoms in mefenamic acidSubcritical water extraction (SWE) process and molecular dynamics simulation (MD) study were performed to investigate mangiferin and antioxidant extraction from the Mahkota Dewa fruits at different operating temperatures (50 ‐ 150 °C). It is suggested that, the intermolecular interaction between OH2O••HMR4(OH1) has been identified to be responsible for the mangiferin extraction process.The objectives of this study were (i) to develop a computational model based on molecular dynamics technique to predict the miscibility of indomethacin in carriers (polyethylene oxide, glucose, and sucrose) and (ii) to experimentally verify the in silico predictions by characterizing the drug-carrier mixtures using thermoanalytical techniques.
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