Such anti-prostaglandin effects may result in clinically significant disease in patients with underlying or preexisting disease that has not been previously diagnosed.Since NSAIDs possess the potential to induce gastrointestinal ulcerations and/or perforations, concomitant use with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. The influence of concomitant drugs that may inhibit metabolism of Metacam 5 mg/mL Solution for Injection has not been evaluated. Available for Android and iOS devices. 0000001237 00000 n
Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction. Metacam ® (meloxicam) 1.5 mg/mL Oral Suspension (equivalent to 0.05 mg per drop) ... be given using the measuring syringe provided in the package (see dosing procedure below). Select one or more newsletters to continue. 0000001350 00000 n
DOGS: The safe use of METACAM Solution for Injection in dogs younger than 6 months of age, dogs used for breeding, or in pregnant or lactating dogs has not been evaluated. Non-steroidal anti-inflammatory drug for use in dogs and cats onlyFederal law restricts this drug to use by or on the order of a licensed veterinarian.Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class.
Diltiazem is well absorbed from the gastrointestinal tract and is subject to an extensive first-pass effect, giving an absolute bioavailability (compared to intravenous administration) of about 40%. Warning: Repeated use of meloxicam in cats has been xref
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To report suspected adverse drug events, for technical assistance or to obtain a copy of the MSDS, contact Boehringer Ingelheim Vetmedica, Inc. at 1-866-METACAM (1-866-638-2226).For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at Peak drug concentrations of 0.734 mcg/mL can be expected to occur within 2.5 hours following a 0.2 mg/kg subcutaneous injection in dogs. The structural formula is:The molecular formula is C22H26N2O4S•HClDiltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. 399 0 obj
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Sensitivity to drug-associated adverse events varies with the individual patient. 0000003374 00000 n
Please refer to the package insert for complete product information.
Renal changes ranged from dilated medullary and cortical tubules and inflammation of the interstitium, to necrosis of the tip of the papilla in 2 of 6 dogs in the 1X group, 2 of 6 dogs in the 3X group, and 4 of 6 dogs in the 5X group.Copyright © 2020 Animalytix LLC. If additional pain medication is needed after the administration of the total daily dose of Metacam Oral Suspension, a non-NSAID or noncorticosteroid class of analgesia should be considered. Safety has not been established for intramuscular (IM) administration in dogs. 0000000796 00000 n
0000055492 00000 n
Commonly used protein-bound drugs include cardiac, anticonvulsant and behavioral medications. H�l��n�0��x[���4 #���!�6�j�ލ=DH�A@���/��Ъ����ΐ?���T�k���'U71 Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. The safe use of Metacam oral suspension in dogs younger than 6 months, dogs used in breeding,or in pregnant or lactating dogs has not been evaluated. The use of concomitantly protein-bound drugs with Metacam 5 mg/mL Solution for Injection has not been studied in dogs. Based upon intravenous administration in Beagle dogs, the meloxicam volume of distribution in dogs (Vdλ) is approximately 0.32 L/kg and the total systemic clearance is 0.01 L/hr/kg. 399 25
0000000016 00000 n
METACAM Solution for Injection. Package Insert for Cats NADA 141-219, Approved by FDA Metacam® (meloxicam) 5 mg/mL Solution for Injection Non-steroidal anti-inflammatory drug for use in dogs and cats only Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cardizem undergoes extensive metabolism in which only 2% to 4% of the unchanged drug appears in the urine. 0000009529 00000 n
The syringe fits on to the bottle and has a scale beginning at 1 lb, designed to deliver the daily maintenance dose (0.05 mg/lb or 0.1 mg/kg). Warning: Repeated use of meloxicam in cats has
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