Metoprolol tartrate tablets should be taken with or immediately following meals.The usual initial dosage of Metoprolol tartrate tablets is 100 mg daily, given in two divided doses. High doses were associated with some maternal toxicity, and growth delay of the offspring in utero, which was reflected in minimally lower weights at birth. Embryotoxicity and/or fetotoxicity in rats and rabbits were noted starting at doses of 50 mg/kg in rats and 25 mg/kg in rabbits, as demonstrated by increases in preimplantation loss, decreases in the number of viable fetuses per dose, and/or decreases in neonatal survival. Gradually increase the dosage at weekly intervals until optimum clinical response has been obtained or there is pronounced slowing of the heart rate. Copy the URL below and paste it into your RSS Reader application. Carcinogenesis, Mutagenesis, Impairment of FertilityTo report SUSPECTED ADVERSE REACTIONS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch The increase in exercise capacity and the reduction in left ventricular ischemia are also significantly related to the logarithm of the oral dose.Patients were randomized and treated as soon as possible after their arrival in the hospital, once their clinical condition had stabilized and their hemodynamic status had been carefully evaluated.
Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.Advise patients to take metoprolol regularly and continuously, as directed, with or immediately following meals. The safety and efficacy of Metoprolol Tartrate Tablets USP in pediatric patients have not been established.No dose adjustment of Metoprolol Tartrate Tablets USP is required in patients with renal impairment.Metoprolol Tartrate Tablets USP blood levels are likely to increase substantially in patients with hepatic impairment. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy. The increase in exercise capacity and the reduction in left ventricular ischemia are also significantly related to the logarithm of the oral dose.In controlled clinical studies, Metoprolol Tartrate has been shown to be an effective antihypertensive agent when used alone or as concomitant therapy with thiazide-type diuretics, at dosages of 100450 mg daily. BetaThe dosage of Metoprolol Tartrate Tablets USP should be individualized. For example, a 50% reduction of the maximum effect after single oral doses of 20 mg, 50 mg and 100 mg occurred at 3.3 hours, 5.0 hours and 6.4 hours, respectively, in normal subjects. Monitor heart rate and rhythm in patients receiving metoprolol tartrate.
The study thus was able to show a benefit from the overall metoprolol regimen but cannot separate the benefit of very early intravenous treatment from the benefit of later beta-blocker therapy. However, greater sensitivity of some elderly individuals taking metoprolol tartrate cannot be categorically ruled out. If a dose should be missed, the patient should take only the next scheduled dose (without doubling it).
It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. During the intravenous administration of metoprolol, monitor blood pressure, heart rate, and electrocardiogram.In patients who tolerate the full intravenous dose (15 mg), initiate metoprolol tartrate tablets, 50 mg every 6 hours, 15 minutes after the last intravenous dose and continue for 48 hours. Treatment with intravenous metoprolol tartrate can be initiated as soon as the patient’s clinical condition allows (see Because of variable plasma levels attained with a given dose and lack of a consistent relationship of antihypertensive activity to dose, selection of In a 21-month study in Swiss albino mice at three oral dosage levels of up to 750 mg/kg per day, benign lung tumors (small adenomas) occurred more frequently in female mice receiving the highest dose than in untreated control animals. Metoprolol tartrate, USP, is a selective beta
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