To comment please Comments on Medscape are moderated and should be professional in tone and on topic.
Drinking to excess is likely to make him pretty sick and is never recommended.Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.Professor of Medicine; Rathmann Family Foundation Endowed Chair for Patient-Centered Clinical Education, University of Washington School of Medicine, Seattle, WashingtonClick the topic below to receive emails when new articles are available. Some drugs may cause a “disulfiram-like reaction” when taken with alcohol. This website also contains material copyrighted by 3rd parties.
Norwegian Medical Association The purported reaction could actually be an alcohol-independent side effect of metronidazole, an effect of alcohol, or disease - possibilities not adequately eliminated by the studies.British National Formulary. Disulfiram-Like Reaction. You must declare any conflicts of interest related to your comments and responses.
Data synthesis: The manufacturer's warnings include a disulfiram-like reaction between metronidazole and ethanol. many of the negative effects.
He graduated from the University of Florida with a Doctor of Pharmacy degree in 2015 and a Master of Healthcare Administration degree from Adventist University in 2017. 2016. 2020. However, review of reports published between 1969 and 1982 produced no convincing evidence that this reaction exists. Please enable it to take advantage of the complete set of features! How Metronidazole Interacts With Alcohol. In the meantime, to ensure continued support, we are displaying the site without styles You can also search for this author in
There have Overall the evidence for this reaction appears to be weak at best. Please confirm that you would like to log out of Medscape.
However, it is possible that disulfiram-like reaction can occur in some subgroups and by other mechanisms than the inhibition of hepatic ALDH. While recovering from an infection, it is important to stay well hydrated and get plenty of rest.Metronidazole has a half-life of about 8 hours. Please enter a Recipient Address and/or check the Send me a copy checkbox. Available at: (accessed April 2020).You can also search for this author in
The metronidazole alcohol mixture introduces the drug into the reaction where the drug blocks the effects of the enzyme.
KNOWLEDGE BASE: The article is based on a review of relevant literature retrieved through a search in PubMed.
It appears likely that the concern attached to it is overstated. Genetic variation of these enzymes causes varying degrees of alcohol metabolism—which is why everyone tolerates alcohol differently. Are Human Challenge Trials for COVID-19 Vaccine Worth the Risk? If you log out, you will be required to enter your username and password the next time you visit. Commenting is limited to medical professionals. Unable to load your delegates due to an error
Take metronidazole, do not drink alcohol. In this case, I would offer the patient the same counsel I would for any similar patient regardless of any medications: A drink or two is unlikely to present a problem. This study shows that metronidazole does not have an effect on blood acetaldehyde concentrations when ingested with ethanol and does not have any objective or subjective disulfiram-like properties.
with alcohol. It began with the theory that because metronidazole blocked hepatic aldehyde dehydrogenase (ALDH) enzyme, it would lead to an accumulation of serum levels of acetaldehyde, the first and major product of alcohol metabolism. Hi! Thank you for visiting nature.com.
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