Giving macrolides or clindamycin during the second trimester of pregnancy to women at risk of preterm births can lower the risk, a new systematic review and meta-analysis by Canadian researchers indicates. Name must be less than 100 characters 2018 General Information on Dry Eyes-Now known as Ocular Surface Disorder Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated with metronidazole for clinical indications, 348 (12.3%) during the first trimester of pregnancy and 553 (19.5%) in the second or third trimester. The use of metronidazole during pregnancy is controversial, especially during the first trimester. Copyright © Vitals Consumer Services LLC pregnancy complications), concerns of potential PTD & LBW with The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. 2000 Dec;62(6):385-92. doi: 10.1002/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z.Sex Transm Dis. There has also been evidence of this drug acting as a carcinogen in rodents. There are no controlled data in human pregnancy.With maternal IV and oral therapy, breastfed infants receive this drug in doses less than those used to treat infections in infants, although the active metabolite adds to the total infant exposure; drug and metabolite plasma levels are measurable, but less than maternal plasma levels. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. 1,4,5,7,18,24,25,26,27 Although treating BV with antibiotics may provide benefit (i.e. Available for Android and iOS devices. We comply with the HONcode standard for trustworthy health information - Animal studies with the oral formulation have failed to reveal evidence of impaired fertility, teratogenicity, or fetal harm at higher doses. The majority of studies did not show an increased risk for congenital anomalies or other adverse fetal outcomes. This drug should be used during pregnancy only if clearly needed.Animal studies with topical formulations have not been reported. Available data on the safety of the drug during pregnancy are contradictory and valid data on the safety of metronidazole in pregnancy are still needed. Think a loved one may be experiencing hearing loss? STUDY DESIGN: All published articles reporting on metronidazole use during pregnancy were screened by two independent reviewers to select those including pregnant patients exposed during the first trimester and comparing the outcomes of their pregnancies with that of patients either not exposed to metronidazole or exposed only during the third trimester.
This drug crosses the placenta and rapidly enters fetal circulation.
1 The agent crosses the placenta throughout gestation.
No increased risk was observed in 3 studies assessing the risk of infant cancer after exposure to this drug during pregnancy; however, these studies had limited ability to detect such a signal. There were 333 (11.8%) preterm births, 262 (9.3%) infants of low birth weight, and 52 infants (1.8%) with congenital anomalies. During pregnancy, treating bacterial vaginosis and trichomoniasis with metronidazole is effective and offers no teratogen risk. Unable to load your collection due to an error During pregnancy, treating bacterial vaginosis and trichomoniasis with metronidazole is effective and offers no teratogen risk. 2020 Apr;23(2):78-83. doi: 10.1016/j.cjtee.2020.02.003. For other indications, metronidazole should be avoided during pregnancy whenever possible, with use occurring only after careful assessment of the potential risk: benefit ratios. A recent study looked at over 900 women who had taken metronidazole sometime during their pregnancy and there was no increased risk for preterm birth (birth before 37 weeks), low birth weight, or congenital anomalies. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action.
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