Minocycline can make birth control pills less effective. • Anticoagulants - tetracyclines depress plasma prothrombin activity and reduced dosages of concomitant anticoagulants may be necessary A single study found that pregnant women taking doxycycline or minocycline may have a higher chance of miscarriage compared to women taking other types of antibiotic. Each drug alone has been associated with pseudotumor cerebri (benign intracranial hypertension) (see 4.4 Special warnings and precautions) It penetrates well into thyroid, lung and liver tissues and in most instances tissue levels exceed serum levels. Nystatin vaginal (Mycostatin) Category B Most antibiotics are Category B, which means that there is no known association with birth defects or other pregnancy-related complication and the drug is probably safe. Minocycline should not therefore be used in pregnancy unless considered essential.The use of drugs of the tetracycline class during tooth development (last half of pregnancy) may cause permanent discoloration of the teeth (yellow-grey brown). • Ergotamine and ergometrine – increased risk of ergotism. All pregnancies have a background risk of birth defects, loss, or other adverse outcome regardless of drug exposure.
Notably, minocycline should not be used to treat acne in pregnant women, since the risks clearly outweigh the benefits.The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. It also appears in tears and saliva.In contrast to most tetracyclines, minocycline appears to undergo some metabolism in the liver, mainly to 9-hydroxyminocycline. This site uses cookies. This blue/black/grey or muddy-brown discolouration may be localised or diffuse. • Oral Contraceptives - both can induce hyperpigmentation. We comply with the HONcode standard for trustworthy health information -
It is also excreted in bile.About a third of the drug may be excreted unchanged and although figures vary widely, about a third of this unchanged drug may appear in the urine and two thirds in the faeces.
There are no controlled data in human pregnancy; however, this drug crosses the placenta and may cause fetal harm.Tetracyclines have been considered contraindicated during breastfeeding due to possible staining of infants' dental enamel or bone deposition of tetracyclines; however, a close review of available literature suggests harmful effects are unlikely with short-term use of this drug during lactation as milk levels are low and infant absorption is inhibited by the calcium in breast milk.LactMed: Short-term use is considered acceptable; as a precaution (theoretical), prolonged or repeat courses should be avoided throughout breastfeeding.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Birth control pills may not work as well while you are using minocycline. Also contains Sunset yellow (E110).Orange, circular, biconvex film-coated tablets, impressed “C” on one face and the identifying letters “M” “N” on either side of a central division line on the reverse.Minocycline is a broad spectrum antibiotic used for the treatment of infections caused by tetracycline-sensitive organisms. Pregnancy category: D. Lactation: Enters breast milk, some manufacturers say do not nurse; however AAP considers nursing compatible due to calcium chelation of drug and prevention of its absorption; long-term safety of prolonged exposure unknown.
• Antacids and Adsorbants - absorption of minocycline is impaired by the concomitant administration of antacids, iron, calcium, aluminium, magnesium and zinc salts (interactions with specified salts, antacids and kaolin).
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