This medication belongs to a group of drugs called calcium channel blockers, which relax blood vessels, making it easier for the heart to pump blood.
Avoid medication errors by using only the form and strength your doctor prescribes.Your blood pressure will need to be checked often and you may need other medical tests.Keep using this medicine even if you feel well. The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure.Nifedipine is completely absorbed after oral administration. Hypersensitivity to nifedipine or other calcium-channel blockers. The increased peripheral vascular resistance, an underlying cause of hypertension, results from an increase in active tension in the vascular smooth muscle. Cardiogenic shock. approximately 8% at 30 mg, 12% at 60 mg and 19% at 90 mg daily.
Rarely, patients, particularly those who have severe
increased in patients with Rare, usually transient, but occasionally significant
My systolic blood pressure is between 140- 152 persistently and diastolic pressure below 80 . shock.Adalat is contraindicated in patients with a known
such as rifampin, are contraindicated since the efficacy of nifedipine tablets
It has a molecular weight of 346.3.
With Adalat CC, these decreases in blood pressure are not accompanied by any significant change in heart rate. peripheral vascular resistance which results in reduced arterial blood
In man, nifedipine decreases peripheral vascular resistance which leads to a fall in systolic and diastolic pressures, usually minimal in normotensive volunteers (less than 5-10 mm Hg systolic), but sometimes larger. Clinical monitoring is recommended and a dose adjustment of nifedipine should be considered.Ketoconazole, itraconazole and fluconazole are CYP3A inhibitors and can inhibit the metabolism of nifedipine and increase the exposure to nifedipine during concomitant therapy. Upward titration should
Patients with tight aortic stenosis may be at greater risk for such an event, as the unloading effect of nifedipine would be expected to be of less benefit to these patients, owing to their fixed impedance to flow across the aortic valve.Because nifedipine decreases peripheral vascular resistance, careful monitoring of blood pressure during the initial administration and titration of Adalat CC is suggested. These dictated the prophylactic placement of a temporary ventricular pacemaker, but otherwise resolved spontaneously. increased half-life and increased Cmax and AUC (See Since this medicinal product contains lactose, patients
The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (SeeNifedipine must not be used in cases of cardiogenic
CYP3A inhibitors such as ketoconazole, fluconazole,
Both contain nifedipine, the coat as a slow release formulation and the core as a fast release formulation. clinical practice suggests that the dosage should be decreased gradually with
Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. exposure to nifedipine during concomitant therapy. Revised: Dec 2015The incidence of adverse events during treatment with
be swallowed whole, not bitten or divided. placebo-controlled clinical trials in 370 The most common adverse event reported with Adalat CC was
results in an inhibition of calcium influx through these channels. Protein binding may be greatly reduced in patients with renal or
Dispense in tight, light-resistant containers.Manufactured for: Bayer HealthCare Pharmaceuticals Inc., Wayne,
The interaction with high dose fentanyl appears to be due to the combination of nifedipine and a beta-blocker, but the possibility that it may occur with nifedipine alone, with low doses of fentanyl, in other surgical procedures, or with other narcotic analgesics cannot be ruled out. patients have not been established.Although small pharmacokinetic studies have identified an
Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. In nifedipine-treated patients where surgery using high dose fentanyl anesthesia is contemplated, the physician should be aware of these potential problems and, if the patient’s condition permits, sufficient time (at least 36 hours) should be allowed for nifedipine to be washed out of the body prior to surgery.Rarely, patients, particularly those who have severe obstructive coronary artery disease, have developed well-documented increased frequency, duration and/or severity of angina or acute myocardial infarction upon starting nifedipine or at the time of dosage increase. Available for Android and iOS devices. Patients recently withdrawn from Rarely, patients (usually while receiving a beta-blocker)
No prolonged sequelae were observed.The effect of a single 900 mg ingestion of nifedipine capsules in a depressed anginal patient on tricyclic antidepressants was loss of consciousness within 30 minutes of ingestion, and profound hypotension, which responded to calcium infusion, pressor agents, and fluid replacement. pregnant women.Nifedipine is excreted in human milk.
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