Nonproductive retching, spilling of oral contents, and drooling were not considered vomiting.
The flash player was unable to start. Further studies are necessary to better assess long term efficacy and safety of ondansetron in this context.Conclusions: Mixed evidence was found via few studies about the efficacy and safety of a single dose of ondansetron in the pediatric population.What is known:• Ondansetron use for vomiting in pediatric acute gastroenteritis is increasing worldwide.• Actual convictions come from studies evaluating one and more than one dose of the drug.What is new:• This is the first review to collect data about the effects of one single dose of ondansetron on strong and temporally homogeneous clinical outcomes.• This study supports the use of one dose of ondansetron in pediatric acute gastroenteritis.• Further studies are necessary to assess its long-term efficacy and safety.
Urticaria developed in one child in the placebo group. In keeping with the World Health Organization (WHO) recommendations on oral rehydration, the caregivers were instructed to limit the amount of fluid given to 30 ml of oral electrolyte solution (Enfalyte, Mead Johnson Nutritionals) every five minutes.On days 3 and 7 after randomization, a research assistant telephoned the child's family and asked, using a standard script, whether the child had returned to an emergency department, had received intravenous-fluid treatment, had had any additional symptoms, or had been hospitalized. Those with a significant effect at the 0.2 level were included in multiple-predictor models. Fixed and random effect models were used for the analyses of pooled data. CAK provided statistical advice on design, sample size estimation, and analyzed the data. doi: 10.1371/journal.pone.0165441. A mixed-effects linear regression model was used for the outcomes of volume of oral-rehydration fluid and volume of intravenous fluid administered, with the physician as the random effect.
Eligible children had at least one reported episode of nonbilious, nonbloody vomiting within the four hours preceding triage, at least one episode of diarrhea during the illness, and mild-to-moderate dehydration (The patients were randomly assigned in blocks of six to receive ondansetron or placebo and were stratified according to the dose of medication. We apologize for any inconvenience. ScienceDirect ® is a registered trademark of Elsevier B.V.A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritisCopyright © 2002 American College of Emergency Physicians.
), Children's Memorial Research Center, Children's Memorial Hospital, Chicago; and the Departments of Pediatrics (M.A., R.S., E.C.P.) -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Between EM:RAP and EMA each month you may earn up to 12 credits a month going forward!
); the Division of Pediatric Emergency Medicine (M.A., E.C.P.) Other variables that were included when appropriate were the number of episodes of vomiting and diarrhea during oral-rehydration therapy and, in the 24 hours before triage, weight change, length of stay in the emergency department, and the type of physician caring for the child (pediatric emergency physician vs. urgent care physician).
Kamal SS, BLK PB, Chandra B, Pathapati RM, Buchineni M: Clinical outcome with single dose ondansetron versus domperidone in paediatric gastroenteritis-our experience.
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