Patients were then randomized to take sumatriptan 100 mg or placebo at 8-hourly intervals for a 7-day period. From Nevrologisk avd, Hedmark Sentralsykehus, Elverum, Norway;the Department of Neurology, Rigshospitalet, Copenhagen, Denmark;Clinica Neuropatologica, Policlinico, Pavia, Italy;the Department of Neurology, Medical Academy of Lodz, Poland andGlaxo Research & Development Ltd, Middlesex, United Kingdom.Glaxo Research & Development Ltd, Middlesex, United Kingdom.Glaxo Research & Development Ltd, Middlesex, United Kingdom.From Nevrologisk avd, Hedmark Sentralsykehus, Elverum, Norway;the Department of Neurology, Rigshospitalet, Copenhagen, Denmark;Clinica Neuropatologica, Policlinico, Pavia, Italy;the Department of Neurology, Medical Academy of Lodz, Poland andGlaxo Research & Development Ltd, Middlesex, United Kingdom.Glaxo Research & Development Ltd, Middlesex, United Kingdom.Glaxo Research & Development Ltd, Middlesex, United Kingdom.Use the link below to share a full-text version of this article with your friends and colleagues. Sweden; P. Henry, M.D., and M. Rosazza, M.D. * The following clinical investigators and research personnel participated in the Sumatriptan Cluster Headache Study Group: K. Ekbom, M.D.
(N Engl J Med 1991; 325:322–6.
)CLUSTER headache is characterized by recurrent, unilateral attacks of headache of great intensity and brief duration, often accompanied by local signs and symptoms of autonomic dysfunction.Among the treatments used for this disorder, orally administered analgesic drugs and ergotamine tartrate have limited value, but the sublingual administration of ergotamine may be beneficial.The cause of cluster headache is unknown, but there are clinical similarities to migraine.
You will be shown how to use the injection. I have read and accept the Wiley Online Library Terms and Conditions of UseAutoinjector device for rapid administration of drugs and antidotes in emergency situations and in mass casualty management, Modern ideas about cluster headache. eCollection 2015.Curr Neuropharmacol.
The patients were assessed clinically and randomly assigned to one of two groups for the treatment of two subsequent attacks of cluster headache. The number of patients requiring rescue medication 15 minutes after injection was compared with Prescott's test.
Adverse events were reported in association with 26 percent of the attacks in which placebo was given, as compared with 35 percent of the attacks treated with sumatriptan. Epub 2017 Sep 6.Ther Clin Risk Manag. One group received 6 mg of sumatriptan for the first attack and placebo for the second attack. More patients preferred sumatriptan than preferred placebo (29 vs. 8, or 74 percent vs. 21 percent); 2 patients expressed no preference.The possibility of a treatment-order interaction was examined, but for all the analyses the tests for period effects and treatment according to period interactions were not significant.Sumatriptan was well tolerated. Clipboard, Search History, and several other advanced features are temporarily unavailable.
Pilgrim, B.M., D.Phil., P.D. Sep 3, 2020 — Hôpital St. Antoine, Paris; J. Hannerz, M.D. Men and women from 18 to 65 years of age were included if they had a history of episodic or chronic cluster headache meeting the criteria of the International Headache Society's Headache Classification CommitteeAny prophylactic therapy was withdrawn at least one week before the study began. van Vliet JA, Bahra A, Martin V, Ramadan N, Aurora SK, Mathew NT, Ferrari MD, Goadsby PJ.Neurology. Persson, M.D. — Neurology Clinic, Medical Academy, Lodz, Poland; M.M. In addition, no drug-related abnormalities were detected in the hematologic or biochemical tests, no electrocardiographic abnormalities developed after treatment with sumatriptan, and there were no significant changes from base line in heart rate or blood pressure.Cluster-headache attacks are relatively short-lived and resolve spontaneously within 15 to 180 minutes,The primary measure of efficacy was the reduction in the severity of headache pain to mild or none, since we considered this the most useful indicator of therapeutic success.
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