Diclofenac binds extensively to plasma albumin. The influence of food on the absorption of diclofenac as a pure substance. Arzneimittel Forschung 1981; 31(12): 2089–92Schneider W, Degen PH. Diclofenac vs nimesulida en artrosis niveles plasmaticos y eficacia clinica. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class. Br J Clin Pharmacol 1997; 43: 104–8Dittrich P, Brunner F. Bioavailability of slow release forms of indomethacin and diclofenac [abstract 3]. J Chromatogr B 1996: 685: 251–63Chan KKH, Vyas KH. Am J Ther 1996; 3: 261–7Junior JP, Pierossi MDA, Muscara MN, et al. Single daily dose of diclofenac retard tablets for the treatment of osteoarthritis. Int J Clin Pharmacol Ther Toxicol 1990; 28(7): 298–302Hasan MM, Najib NM, Rawashdeh NM, et al. Arzneimittel Forschung 1996; 46(1): 57–63Ramakrishna S, Fadnavis NW, Diwan PV. When given orally the absorption of diclofenac is rapid and complete. Drug Des Deliv 1989; 4: 303–11Brunner LA, Luders RC. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Lancet 1989; II: 1154Fellows IW, Clarke JMF, Roberts PF. Pharm Res 1989; 6(9 Suppl. J Ocul Pharmacol 1994; 10(4): 677–82Gelderen MEM, Olling M, Barends DM, et al. Percutaneous absorption of diclofenac in rats and humans: aqueous gel formulation. However, 1:1 ratio mixture of the polymer (Eudragit® RS/RL = unloaded or no drug) that was used as the matrix base showed two different melting endothermic peaks (The physical properties that determine the flow characteristics of microspheres are expressed in terms of Carr’s index and angle of repose (The bulk and tapped densities as well as the compressibility index and angle of repose of the microspheres formulated with different ratios of the Eudragit® RS/RL-loaded DS are presented in There were also slight variation in the compressibility indices and the angle of repose of the loaded microsphere in comparison with unloaded batch (DF-0).
Eur J Clin Pharmacol 1981; 19: 33–7Willis JV, Jack DB, Kendall MJ, et al. Paris: Clermont-Ferrrand, 1981: 447–55Henrikson P-Á, Thilander H, Wåhlander LÅ. It was observed that the increase in the diffusional length prevented the ease of drug migration as a result of polymer-drug complex formation, which takes longer time to hydrate before the drug can be expelled or migrate from the core matrix. Over 10 million scientific documents at your fingertips Biochem Pharmacol 1985; 34(10): 1695–1700Köhler G, Mohing W. Zur kinetik von diclofenacna in plasma und synovialflüssigkeit. In this study, DS-loaded microspheres based on biodegradable Eudragits were successfully prepared by the solvent-evaporation technique, which is simple, cheap and reproducible.
Int J Clin Pharmacol Ther Toxicol 1993; 31(8): 389–91Scheidel B, Blume H, Walter K, et al. This powder was added to 5 ml of ethanol and was allowed to dissolve completely and 5 ml of phosphate buffer (pH 7.4) was added to this solution and mixed thoroughly. Lancet 1991; 337: 252Schumacher A, Geissler HE, Mutschler E, et al. Mitteilung. Dose-proportionality of diclofenac sodium (Voltaren®) in man. Pharmacokinetic and Pharmacodynamics of Sodium Diclofenac (Topical and IM) Associated with Laser Photobiomodulation on Skeletal Muscle Strain in Rats Rodrigo Leal de Paiva Carvalho , 1 P. S. L. M. Leonardo , 2 Gustavo Duarte Mendes , 3 , 4 Fernanda Púpio Silva Lima , 5 Mário Oliveira Lima , 5 Rodrigo Labat Marcos , 6 and Rodrigo Alvaro Brandão Lopes-Martins 2
1): 65–7Liauw H, Walter S, Lee L, et al. NsukkaNigeria Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria
An automated method for the determination of diclofenac sodium in human plasma. Diclofenac combined with cyclosporine in treatment of refractory rheumatoid arthritis: longitudinal safety assessment and evidence of a pharmacokinetic/dynamic interaction. Sensitive method for the determination of diclofenac in human plasma by gas chromatography-mass spectrometry. Comparative pharmacokinetic analysis of a novel sustained-release dosage form of diclofenac sodium in healthy subjects. The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazide. Eudragit® RS-100 and RL-100 were gifts from Evonik, GmbH (Darmstadt, Germany). Biomed Environ Mass Spectrom 1988; 16: 361–5Grandjean D, Beolar JC, Quincon MT, et al. Determination of total monohydroxylated metabolites of diclofenac in urine by electron-capture gas-liquid chromatography. Int J Pharm 1988; 46: 1–7Cassidy J, Berner B, Chan K, et al. Diclofenac sodium: blood concentration of the slow-release from and influence on the metabolism of kallikrein. Int J Clin Pharmacol Ther Toxicol 1991; 29(3): 178–83Mustofa M, Suryawati S, Dwiprahasto I, et al. Markedly reduced intestinal toxicity of a diclofenac derivative. 78 Higher levothyroxine doses were reportedly required in patients with coeliac disease and when patients followed a gluten-free diet, levothyroxine dose requirement was reduced. Life Sci 1994; 55(1): 1–8Wallace JL, Reuter B, Cicala C, et al. Biopharm Drug Disp 1991; 12: 411–24Deakin M. Small bowel perforation associated with an excessive dose of slow release diclofenac sodium. Transsynovial drug distribution: synovial mean transit time of diclofenac and other nonsteroidal antiinflammatory drugs. Determination of diclofenac sodium in synovial fluid by high performance liquid chromatography.
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