and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Note that any depressant effects of promethazine HCl are not reversed by naloxone. The inactive ingredients present are lactose, magnesium stearate, and methylcellulose.
These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. required for the performance of potentially hazardous tasks, such as driving
The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see Promethazine HCl Oral Solution may lead to potentially fatal respiratory depression.Use of Promethazine HCl Oral Solution in patients with compromised respiratory function (e.g. fatal respiratory depression. Oxygen may also be administered.Limited experience with dialysis indicates that it is not helpful.It is important that Promethazine HCl Oral Solution is measured with an accurate measuring device (see The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Promethazine is a racemic compound. Ambulatory patients should be told to avoid engaging in such activities until it is known that they do not become drowsy or dizzy from promethazine therapy. Read all information given to you. following structural formula:Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. Acidosis and electrolyte losses should be corrected. The concomitant use of alcohol or other central-nervous-system depressants,
There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered.Excessively large dosages of antihistamines, including Promethazine HCl Oral Solution, in pediatric patients may cause sudden death (see Administration of promethazine HCl has been associated with reported cholestatic jaundice.Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.Promethazine HCl Oral Solution should be used cautiously in persons with cardiovascular disease or with impairment of liver function.Patients should be advised to measure Promethazine HCl Oral Solution with an accurate measuring device. measuring device (see Promethazine HCl Syrup (promethazine hydrochloride syrup plain) Plain is contraindicated for children under 2 years
Rev 03/08. Convulsions may rarely occur. a vehicle or operating machinery. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-desmethylpromethazine are the predominant metabolites appearing in the urine.Allergic conjunctivitis due to inhalant allergens and foods.Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.Amelioration of allergic reactions to blood or plasma.Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.Preoperative, postoperative, or obstetric sedation.Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.Active and prophylactic treatment of motion sickness.Promethazine HCl Oral Solution is contraindicated for use in pediatric patients less than two years of age.Promethazine HCl Oral Solution is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma.Promethazine HCl Oral Solution may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.
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