Saving Lives, Protecting People January 2005.World Health Organization: "Post-exposure prophylaxis to prevent HIV infection," December 2014.AIDS.gov: "Overview of HIV Treatments," "Post-Exposure Prophylaxis (PEP). Most importantly, PEP is only taken for 28 days. PEP should be used only in emergency situations. PEP must be started within 72 hours (3 days) after a possible exposure to HIV. You can read an overview of PEP here.PEP should not be confused with pre-exposure prophylaxis (PrEP), which involves taking medicine on an ongoing basis, before possible exposure to HIV.. Registered charity, number: 1011220NAM exists to support the fight against HIV & AIDS with independent, accurate accessible and comprehensive information. ANSWER You might have nausea or fatigue with PEP. Additionally, people whose sexual or injection-related exposures result in concurrent acquisition of HCV and HIV infection might have delayed HIV seroconversion.In many states, PEP is covered by insurance, including Medicaid. It may be localised in one part of the body or affect all the skin. NAM is not responsible for the content of external websites.Company limited by guarantee. Initiation of post-exposure prophylaxis with the use of antiretroviral drugs is dependent on a number of risk factors, though treatment is usually started after one high-risk event. For example, taken together, one medicine may increase the side-effects of another medicine.It is important to tell your doctor or pharmacist about all other medicines and drugs that you are taking – this includes those prescribed by another doctor; over-the-counter medicines (including inhalers and nasal sprays); supplements, herbal and alternative treatments; and recreational drugs.The University of Liverpool provides an online tool to check for interactions between anti-HIV drugs, other medications and recreational drugs. Examples of those commonly experienced include nausea and vomiting, dizziness, headache, and muscle pain and weakness. PEP stands for post-exposure prophylaxis. In almost all cases, the benefits of HIV prevention outweigh any other risks posed by the medication. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. If you develop a rash with other symptoms, such as a fever, seek medical advice.Dolutegravir is an integrase inhibitor that may be prescribed (50mg) once daily, as an alternative to raltegravir.
1-888-448-4911 9 a.m. – 2 a.m. 2014 Oct 246:147-58. doi: 10.2147/HIV.S46585. The purpose of a low dose of ritonavir is to ‘boost’ and maintain levels of the main protease in the body.Boosted protease inhibitors that may be prescribed include lopinavir, darunavir or atazanavir.Lopinavir (200mg) and ritonavir (50mg), taken twice daily, frequently causes diarrhoea and other gastrointestinal disturbances.Other common side-effects (over 1% of people) include: nausea, sinus or throat infections, pancreatitis, vomiting, abdominal pain, bloating, flatulence, heartburn and indigestion, loss of appetite, raised lipids or blood sugar, diabetes, high blood pressure, rash, itching, skin infections, dizziness, tiredness, difficulty in sleeping, anxiety, weakness, headache, haemorrhoids, raised liver enzymes, allergic reaction including swelling, infections in the respiratory tract, cough, sore throat, runny nose, erectile dysfunction, menstrual disorders, peripheral nerve damage, muscle pain.Darunavir (800mg) may be prescribed with ritonavir (100mg) once daily.Common side-effects of darunavir (over 1% of people) include: diarrhoea, vomiting, nausea, abdominal pain, bloating, indigestion, flatulence, headache, tiredness, dizziness, drowsiness, numbness, peripheral neuropathy (damage to nerves in the hands or feet causing tingling or pain), insomnia, weakness, rash, itching, diabetes, raised lipids, raised liver enzymes.Atazanavir (300mg) may be prescribed with ritonavir (100mg) once daily.Common side-effects of atazanavir include: headache, nausea, vomiting, diarrhoea, abdominal pain, indigestion, tiredness, rash, and raised bilirubin levels. Department of Health and Human Services: "Antiretroviral Postexposure Prophylaxis After Sexual, Injection-Drug Use, or Other Nonoccupational Exposure to HIV in the United States." We believe independent, clear and accurate information is vital in the fight against HIV & AIDS.Our information is intended to support, rather than replace, consultation with a healthcare professional. 2 FDA’s emergency dispensing order applies to all FDA-approved oral dosage forms of doxycycline products for the post-exposure prophylaxis of inhalation anthrax during an emergency involving B. anthracis.For details, see www.fda.gov External. Some possible long-term complications that are listed (such as raised liver enzymes) are highly unlikely to occur during a one-month course of the medication.The recommended combination treatment of emtricitabine (200mg) and tenofovir (245mg) once daily, and raltegravir (400mg) every 12 hours is well tolerated.That said, common side-effects (over 1% of people) of raltegravir include: loss of appetite, headache, difficulty in sleeping, abnormal dreams, depression, dizziness, vertigo, abdominal pain, bloating, flatulence, Rarely, raltegravir can cause a hypersensitivity (allergic) reaction. Emergency medicine physicians are among the most frequent prescribers of PEP, given the need for immediate treatment after exposure.
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