Some neonates recovered within hours or days without specific treatment; others required prolonged hospitalization.Published data from observational studies, birth registries, and case reports on the use of atypical antipsychotics during pregnancy do not report a clear association with antipsychotics and major birth defects. Therefore, ziprasidone should not be given with:Ziprasidone is contraindicated in individuals with a known hypersensitivity to the product.Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. To administer a 10 mg dose, draw up 0.5 mL of the reconstituted solution. If sympathomimetic agents are used for vascular support, epinephrine and dopamine should not be used, since beta stimulation combined with αIn cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. It is particularly important to tell your doctor if you have diarrhea, vomiting, or another illness that can cause you to lose fluids. Nevertheless, ziprasidone's larger prolongation of QTc length compared to several other antipsychotic drugs raises the possibility that the risk of sudden death may be greater for ziprasidone than for other available drugs for treating schizophrenia. Protect from light.
They are supplied in the following strengths and package configurations:Geodon for Injection is available in a single-dose vial as ziprasidone mesylate (20 mg ziprasidone/mL when reconstituted according to label instructions) Because of ziprasidone's dose-related prolongation of the QT interval and the known association of fatal arrhythmias with QT prolongation by some other drugs, ziprasidone is contraindicated:Pharmacokinetic/pharmacodynamic studies between ziprasidone and other drugs that prolong the QT interval have not been performed. Of these 5700, over 4800 were patients who participated in multiple-dose effectiveness trials, and their experience corresponded to approximately 1831 patient-years. In the same long-term studies, the proportion of subjects with ≥ 7% increase in weight from baseline for ziprasidone 20-40 mg BID was 5.6% (N=124); for ziprasidone 60-80 mg BID was 20.0% (N=10), and for placebo was 5.6% (N=72).
In clinical trials with oral ziprasidone, the electrocardiograms of 2/2988 (0.06%) patients who received GEODON and 1/440 (0.23%) patients who received placebo revealed QTc intervals exceeding the potentially clinically relevant threshold of 500 msec. It is not known if this is a direct result of the illness or other comorbid factors.Extrapyramidal and/or withdrawal symptoms, including agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, and feeding disorder have been reported in neonates who were exposed to antipsychotic drugs, including Geodon, during the third trimester of pregnancy. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. Single-dose vials require reconstitution prior to administration.Add 1.2 mL of Sterile Water for Injection to the vial and shake vigorously until all the drug is dissolved. Somnolence led to discontinuation in 0.3% of patients in short-term clinical trials. In a second 3-week placebo-controlled trial (n=205), the dose of ziprasidone was 40 mg twice daily on Day 1. The conditions and duration of treatment with ziprasidone included open-label and double-blind studies, inpatient and outpatient studies, and short-term and longer-term exposure.Clinical trials for intramuscular ziprasidone included 570 patients and/or normal subjects who received one or more injections of ziprasidone. According to the AAP, health care providers should weigh the risks and benefits when prescribing medications to breastfeeding mothers by considering the following:Tell your health care provider and your baby’s provider about any medications or supplements you are taking, including vitamins, herbs, and over-the-counter products.The US National Library of Medicine (NLM) at the National Institutes of Health (NIH) maintains The Organization of Teratology Information Specialists (OTIS) provides information, in English and Spanish, for women and health care providers on the risks and safety of taking medication during pregnancy and breastfeeding. During long-term therapy with ziprasidone, a categorization of patients at baseline on the basis of During a 6-month placebo-controlled bipolar maintenance study in adults with ziprasidone as an adjunct to lithium or valproate, the incidence of clinically significant weight gain (≥ 7% of body weight) during the double-blind period was 5.6% for both ziprasidone and placebo treatment groups who completed the 6 months of observation for relapse.
Geodon (ziprasidone) is an antipsychotic medication.
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