Primolut-n is norethisterone progesterone (testosterone derivative) unlike susten which is natural micronised progesterone. • jaundice and/or pruritus related to cholestasis In women with hereditary angioedema exogenous estrogens may induce or exacerbate symptoms of angioedema.Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal. Some epidemiological studies have indicated that long-term use of COCs may further contribute to this increased risk but there continues to be controversy about the extent to which this finding is attributable to confounding effects, e.g., cervical screening and sexual behaviour including use of barrier contraceptives.A meta-analysis from 54 epidemiological studies reported that there is a slightly increased relative risk (RR = 1.24) of having breast cancer diagnosed in women who are currently using COCs. By continuing to browse the site you are agreeing to our policy on the use of cookies. After the cessation of drug therapy enzyme induction may be sustained for about 4 weeks.Phenytoin, barbiturates, bosentan, primidone, carbamazepine, rifampicin and HIV medication ritonavir, nevirapine and efavirenz, and possibly also oxcarbazepine, topiramate, felbamate, griseofulvin and products containing St. John's wort (Hypericum perforatum).When co-administered with sex hormones, many HIV/HCV protease inhibitors and non-nucleoside reverse transcriptase inhibitors can increase or decrease plasma concentrations of estrogen or progestin. hepatic, mesenteric, renal, cerebral or retinal veins and arteries, in COC users. The use of a combined oral contraceptive may also increase the risk of conditions such as stroke and myocardial infarction which are secondary to arterial thromboembolic events. Suggestions offered by doctors on Lybrate are of advisory nature i.e., for educational and informational purposes only. The medicine may also interact severely with the following medicines: Primolut N is used primarily used to treat abnormal vaginal bleeding and menstrual disorders. tizanidine) increase in plasma concentration.Concomitant use with the medicinal products containing ombitasvir/paritaprevir/ritonavir and dasabuvir, with or without ribavirin may increase the risk of ALT elevations (see sections 4.3 and 4.4). Previous or existing liver tumours (benign or malignant).12. Postponement of menstruation. Comments (0) Add a comment. ▪ Pending operations (six weeks beforehand), immobilisation (e.g. Primolut N should not be used in the presence of any of the conditions listed below. Primolut N tables consist of an active ingredient, norethistherone, a synthetic composition of the female hormone, progesterone. Drug interactions differ from one individual to the other. 0000009639 00000 n For the drug to be sold it is mandatory to have a doctor’s prescription. There are no special antidotes, and treatment should be symptomatic. 0000004779 00000 n Reproduction toxicity studies showed the risk of masculinisation in female fetuses when administered at high doses at the time of the development of the external genitalia. The interaction of this medicine with alcohol is unknown but it is advisable to consult the doctor before taking this medicine. Dysmenorrhoea.To ensure treatment success, Primolut N must be taken for the full 10 days. 0000008771 00000 n I have tested my urine wait the pregnancy test tube (HCG test tube). 0000003244 00000 n 1. Known or suspected pregnancy. polyps, carcinoma of the cervix uteri or endometrium, myoma, residua of abortion, extra-uterine pregnancy, or coagulation disorders) must be considered so that other measures are then mostly required. Content posted on, created for, or compiled by Lybrate is not intended or designed to replace your doctor's independent judgment about any symptom, condition, or the appropriateness or risks of a procedure or treatment for a given person.
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