women.4 QTc prolongation is easier to spot if computer interpreted 12 lead electrocardio-grams are available, with their routine printout of QT and QTc intervals.QTc values >500 ms should prompt review of the patient’s drug therapy in the light of the catalogue of potential QT prolongation due to roxithromycin … Clipboard, Search History, and several other advanced features are temporarily unavailable.
*p < 0.01, †p < 0.001, ‡p < 0.0001 when compared with initial value in the same group.In both groups, the clinically relevant side effects of sedative administration were not detected.
Forty patients were randomly allocated to receive promethazine (25 mg) or midazolam (2.5 mg). Patients were also excluded if they had any history of hypersensitivity to promethazine or midazolam or pre‐operative electrolytic imbalances.A randomisation scheme was generated using the pseudo‐random number generator of Wichmann and Hill, modified by McLeod (available at Participants were not medicated before arrival in the operating theatre. *p < 0.001, †p < 0.00 005, ‡p < 0.0001 all compared with initial value in the same group.
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General contraindications to these agents: Parkinson's disease New electrocardiographic characteristicsTorsade de pointes induced by psychotropic drugs and the prevalence of its risk factorsPromethazine affects autonomic cardiovascular mechanisms minimally“Conventional” antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline heartsDifferences of promethazine and terfenadine on ion channels in guinea pig ventricular myocytesA comparison of the effect on dispersion of repolarization of age‐adjusted MAC values of sevoflurane in childrenThe effect of intravenous lidocaine on QT changes during tracheal intubationAnaesthetics and the rate corrected interval: learning from droperidol?Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndromeAcquired long QT syndrome and elective anesthesia in childrenEvaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetistOral ketamine/midazolam is superior to intramuscular meperidine, promethazine, and chlorpromazine for pediatric cardiac catheterizationThe risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine, Gastric electrical stimulation: An emerging therapy for children with intractable gastroparesis, Current and future treatment management strategies for gastroparesis, Perioperative management of patients with congenital or acquired disorders of the QT interval, Does promethazine shorten the length of stay in the post anesthesia care unit?, Antiémétiques et effets cardiaques potentiellement liés à un allongement de l’intervalle QT : analyse cas/non-cas dans la Base nationale de pharmacovigilance, The Effect of Antiemetics and Antihistamines on the QTc Interval in Emergent Dialysis Patients With Baseline QTc Prolongation, Emerging strategies for the treatment of gastroparesis, Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity, Low dosage promethazine and loratadine negatively affect neuromotor function, A worldwide yearly survey of new data in adverse drug reactions, Drug-induced QT interval prolongation in cancer patients,
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Nausea and vomiting are enormously uncomfortable and potentially dangerous (e.g., due to aspiration or inability to take oral medication). 7"]T:rAX$fZSWUZ3>NKb+l5ldaYu`KcdG3tI'=((7bV802P%#MW]0D$Ekp4fKEBR5 4Tg*#KE=;0N@YZ)/)qBT@-S4*Xule%-Vm#ZK?as;)S0rQ9 We reported a 6‐year‐old girl who developed torsade de pointes (TdP) after taking roxithromycin.
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