13. including the Approximately 70% of an oral dose is excreted in the You are encouraged to report negative side effects of prescription drugs to the FDA. ( Singapore Tuberculosis Service/British Medical Research Council. Bioassay of pyrazinamide for possible carcinogenicity. 1. We comply with the HONcode standard for trustworthy health information - Roman IC, Georgian L. Cytogenetic effects of some antituberculosis
Your symptoms may improve before the infection is completely cleared. Carafate; Canadian Brand Name. 48, 1978.7.
Drug Information, American Hospital Formulary Service. Stamathakis G, Montes C, Trouvin JH, et al. Available for Android and iOS devices. Pyrazinamide may be bacteriostatic or bactericidal against Mycobacterium tuberculosis depending on the concentration of the drug attained at the site of infection. liver function tests developed. their situation.Pyrazinamide frequently will be an important component of such therapy.Patients with concomitant HIV infection may require longer courses of therapy.
You may need to take pyrazinamide for only the first 2 months of your full course of treatment.Pyrazinamide is usually taken once per day. In one case report of overdose, abnormal Pyrazinamide Skipping doses may also increase your risk of further infection that is resistant to Tell your doctor if you have any changes in weight. Treatment of tuberculosis and tuberculosis infection in adults Pyrazinamide is exactly the oppositeThe research support (to Y.Z.) Do not use this medicine in larger or smaller amounts or for longer than recommended.Tuberculosis must be treated over a long period of time (up to 6 months or longer).Pyrazinamide is given in combination with other medications and should not be used alone. Because conversion of the prodrug pyrazinamide into pyrazinoic acid by PZase is slow in To determine whether pyrazinoic acid inhibits the membrane transport of amino acids, we examined the effect of pyrazinoic acid on the uptake of Weak acids are proton carriers at acid pH that could potentially decrease the membrane potential required for the transport of various nutrients. Patients started on pyrazinamide should have baseline serum Pyrazinamide should be discontinued and not be resumed if signs of hepatocel-lular 5. PZA kills nonreplicating persisters that other TB drugs fail to kill, which makes it an essential drug for inclusion in any drug combinations for treating drug-susceptible and drug-resistant TB such as multidrug-resistant TB. Your doctor may occasionally change your dose to make sure you get the best results. Holdiness M. Antituberculosis drugs and breast-feeding. regimen for drug-susceptible patients.
Pyrazinamide must be used with other TB medicines. and pyrazinoic acid pharmacokinetics in patients with Overdosage experience is limited. in dose. PRECAUTIONS: Before taking pyrazinamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA Dosage, drug interactions, and pregnancy and breastfeeding safety information are provided. However, the mechanism of action of pyrazinamide is poorly understood because of its unusual properties. Pyrazinamide is dialyzable.13. agents.Pyrazinamide should always be administered with other effective antituberculous Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in shortening TB therapy. Pyrazinamide is an antibiotic used against Mycobacterium tuberculosis . Pyrazinamide is a prodrug and it undergoes hydrolysis and forms the active metabolite Pyrazinoic acid. PZA kills nonreplicating persisters that other TB drugs fail to kill, which makes it an essential drug for inclusion in any drug combinations for treating drug-susceptible and drug-resistant TB such as multidrug-resistant TB. Common side effects are dizziness, insomnia, diarrhea, nausea, and vertigo.
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