Available for Android and iOS devices. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).Avoid drinking alcohol. The awareness of the side effects of repaglinide was 21.6% (without insulin therapy) versus 21.4% in the insulin-comedicated group. About half of the patients had an inadequate response to previous methotrexate monotherapy, and about half of the patients were methotrexate naive. Both formulations are only indicated for use in children at least 6 years of age (see Dosage).Sulfasalazine is contraindicated in patients with GI obstruction. Select a medication above to begin. Applies to: Adrenal Insufficiency, Malnourished, Panhypopituitarism, Autonomic Neuropathy, Anorexia/Feeding ProblemsHypoglycemia may commonly occur during treatment with insulin and/or oral hypoglycemic agents.
Sulfasalazine is classified as FDA pregnancy risk category B. Sulfasalazine and sulfapyridine (an active moiety) cross the placenta. Sulfasalazine should be avoided in asthmatics with a history of aspirin-induced bronchospasm.
Repaglinide Rofecoxib Rosiglitazone Salicylic Acid Salsalate Saxagliptin Sitagliptin Sodium Salicylate ... sulfamethoxazole, sulfasalazine, sulfisoxazole, Azulfidine®, Bactrim®, or Septra®)—Severity and duration of allergic reactions to other substances may be increased. Drug interactions . Isolated cases have been reported where sulfasalazine enteric-coated tablets have passed undisintegrated. Sunscreens should be employed, but may provide limited protection for this reaction. Due to structural similarity to sulfonamides, patients with furosemide hypersensitivity, thiazide diuretic hypersensitivity, sulfonylurea hypersensitivity, or carbonic anhydrase inhibitor hypersensitivity should use sulfasalazine with caution. Slow acetylators have been associated with an increased incidence of adverse effects, perhaps due to increased sulfapyridine concentrations.Approximately 20% of an oral dose is absorbed as unchanged sulfasalazine from the small intestine. Furthermore, the AAP classifies 5-ASA as a drug that should be given to nursing mothers with caution; diarrhea has been reported with maternal use of 5-ASA agents, including sulfasalazine, during breast-feeding. Alkalinization of the urine may increase the solubility of sulfasalazine in patients with low urine output or if the urinary pH is low. Select one or more newsletters to continue. Patients with type 2 diabetes who have severe renal function impairment should initiate repaglinide therapy with the 0.5 mg dose and subsequently, patients should be carefully titrated.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. action of biguanides. Total doses of more than 4 g/day may increase the risk of adverse effects and toxicity. Wait until your next meal.Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination.Repaglinide is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Other evidence suggests that sulfasalazine does not appear to be associated with a significant risk of teratogenicity, with published case control series not finding an increase in congenital anomalies.
Initially, 3—4 g/day PO in evenly divided doses (at least every 8 hours). Sulfonamides, such as sulfapyridine, are generally considered category D when used near term due to the potential for jaundice, hemolytic anemia, and kernicterus in the newborn; therefore, caution is warranted for use in pregnancy near term. According to the manufacturer, sulfasalazine should be used with caution in women who are breast-feeding. Other evidence suggests that sulfasalazine does not appear to be associated with a significant risk of teratogenicity, with published case control series not finding an increase in congenital anomalies. Unchanged sulfasalazine does not cross into breast milk in appreciable amounts; however, the active moieties (i.e., sulfapyridine, a sulfonamide and mesalamine) do enter the milk in small quantities. The antiinflammatory mechanism of mesalamine is believed to occur, at least in part, through the inhibition of arachidonic acid metabolism in the bowel mucosa by inhibition of cyclooxygenase. In general, other agents that do not contain a sulfonamide, such as mesalamine and balsalazide, may be preferred; the nursing infant should be observed for any persistent changes in bowel habits (e.g., persistent increase in stool frequency).
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