Although not all of these side effects may occur, if they do occur they may need medical attention. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Ltd., Gujarat, India) 400 mg three times daily for one month might reduce levels of fat and sugar in the blood in people … Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes.
The study would be declared successful if at least one of the three primary hypotheses was met.During Phase 2, participants receive up to 6 mg glimepiride daily as an add-on to metformin + sitagliptin combination therapy for 24 weeks (Week 20 through Week 44).Metformin, 500 mg or 850 mg oral tablets, twice or three times a day (BID or TID) for a total dose of at least 1500 mg daily; administered with food.Sitagliptin, 100 mg oral tablet, once daily (QD); administered with or without foodGlimepiride, 1 mg and/or 2 mg oral tablets, QD (up to 6 mg daily); administered before the first main meal of the dayDuring Phase 2, participants receive up to 16 mg repaglinide daily as an add-on to metformin + sitagliptin combination therapy for 24 weeks (Week 20 through Week 44).Metformin, 500 mg or 850 mg oral tablets, twice or three times a day (BID or TID) for a total dose of at least 1500 mg daily; administered with food.Sitagliptin, 100 mg oral tablet, once daily (QD); administered with or without foodRepaglinide, 0.5 mg and/or 1 mg oral tablets, TID (up to 16 mg daily); administered within 30 minutes of each meal.During Phase 2, participants receive 50-100 mg acarbose three times daily as an add-on to metformin + sitagliptin combination therapy for 24 weeks (Week 20 through Week 44).Metformin, 500 mg or 850 mg oral tablets, twice or three times a day (BID or TID) for a total dose of at least 1500 mg daily; administered with food.Sitagliptin, 100 mg oral tablet, once daily (QD); administered with or without foodAcarbose, 50 mg oral tablets, TID (150 mg total daily dose); administered with the first bite of each main meal.During Phase 2, participants receive 30-120 mg gliclazide daily as an add-on to metformin + sitagliptin combination therapy for 24 weeks (Week 20 through Week 44).Metformin, 500 mg or 850 mg oral tablets, twice or three times a day (BID or TID) for a total dose of at least 1500 mg daily; administered with food.Sitagliptin, 100 mg oral tablet, once daily (QD); administered with or without foodGliclazide, 30 mg oral tablets, QD or BID (30 mg to 120 mg total daily dose); administered with meal.HbA1c is blood marker used to report average blood glucose levels over prolonged periods of time and is reported as a percentage (%). The percentage of participants with hypoglycemia events was reported.The percentage of participants with a GI AE of "nausea" was reported.The percentage of participants with a GI AE of "vomiting" was reported.The percentage of participants with a GI AE of "diarrhea" was reported.The percentage of participants with a GI AE of "abdominal pain" was reported. Methods: The literature research dating up to August 2018 was conducted in … A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Participants coming on study will be stabilized to a standardized metformin dose: this may take about 10 weeks, and then combination therapy with metformin + sitagliptin will begin during Phase 1 (Week 0 through Week 20). Change from baseline reflects the Week 44 body weight minus baseline body weight.
Objective and Design Gliclazide has been associated with a low risk of hypoglycemic episodes and beneficial long-term cardiovascular safety in observational cohorts. in a study comparing effects of repaglinide and glimepiride on overall glycemic control. Glimepiride is taken once a day (typical dose: 1 mg to 4 mg; maximum 8 mg daily) Meglitinides are usually taken 15-30 minutes before each meal: Repaglinide is taken at doses ranging usally from 0.5 mg to 4 mg with each meal
Similar results were demonstrated by Derosa et al. Change from baseline reflects the Week 44 A1C minus baseline A1C. Baseline is defined as Visit 6/Week 20. COVID-19 is an emerging, rapidly evolving situation. Baseline is defined as Visit 6/Week 20. ScienceDirect ® is a registered trademark of Elsevier B.V.Repaglinide has more beneficial effect on cardiovascular risk factors than glimepiride: data from meal-test studyCopyright © 2005 Elsevier Masson SAS. If this measurement was unavailable, the Week 16 value was used.
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