As with all herbal supplements, chamomile hasn't been tested for safety in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications. Some reports have shown that several types of statins enhance the anticoagulant effect of vitamin K antagonists as a result of anticoagulant drug metabolism inhibition or by a reduction of lipoprotein-dependent vitamin K absorption and hepatic storage.Because the current study shows that statins increase the risk of intracerebral hemorrhage in patients with a history of cerebrovascular disease, one could hypothesize that statin treatment also increases the risk of other major bleedings such as gastrointestinal hemorrhages. Lexicomp's Drug Information Handbook. First, we considered that all patients in the HPS and SPARCL studies with unclassified stroke had hemorrhagic stroke. Sometimes, taking a combination of cholesterol drugs can provide the same result with lower doses of statins. Statin-related DDIs can range from mild muscle aches or weakness to a … This is a general list of medical conditions and medications that you should be aware of: But it is theoretically possible to occur with use of the following drugs, which are metabolized by CYP1A2, in combination with chamomile: As a result of this and other reports, healthcare providers advise against consuming chamomile while taking anti-rejection drugs. This article outlines the current knowledge regarding the use of these three drug classes in patients who have heart failure. Anticoagulants, or “blood thinners,” are used to reduce the risk of blood clots and stroke.
Therefore, the analysis of the risk of ischemic and hemorrhagic stroke was based on 8011 patients. In total, 4008 patients were randomized to statin treatment and 4003 patients to placebo. When statins are combined with one or more of these other heart medications, a DDI can occur. For these reasons, it's important that you discuss your medical history and everything you are taking with your doctor. In case the χBesides the HPS and SPARCL studies, our systematic search revealed 2 additional randomized, controlled trials in which the effect of statins on stroke prevention was investigated in subgroups of patients. E-mail © American Heart Association, Inc. All rights reserved. Although statins are the most effective oral medications for lowering your cholesterol, other types of drugs also are available. Ⓒ 2020 About, Inc. (Dotdash) — All rights reservedYasmine Ali, MD, is board-certified in cardiology. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study was designed to study this question prospectively.The results of the SPARCL study also show that statins appear to increase the occurrence of hemorrhagic stroke. ANTICOAGULANTS/ ANTIPLATELETS (continued page 2) Ex: Coumadin/Warfarin, Aspirin, ... of Zyprexa or Clozaril and this increased potential for side effects. Chamomile has compounds that inhibit drug-metabolizing enzymes of the human cytochrome P450 family (CYP1A2, CYP2C9, CYP2D6, and CYP3A4). Heparins should be used in most patients who require prevention of venous thromboembolism. Coumadin (warfarin) along with a statin may reduce the blood's ability to clot. This includes any medical conditions you may have or any medications you are taking. Vergouwen, MD, Department of Neurology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Consider other cholesterol-lowering medications. Statin treatment could be more effective if not given to patients with an increased risk of hemorrhagic stroke. In total, 4008 patients were randomized to statin treatment and 4003 patients to placebo. Always read the package insert to identify the drug interactions specific to the statin you are taking, whether it is In patients randomized to statin treatment, 318 patients had ischemic stroke and 76 had hemorrhagic stroke.
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