Decreased cholesterol production leads to an increase in the number of LDL membrane receptors, which increases clearance of LDL cholesterol from circulation. Two randomized controlled trials specifically assessed the development of myalgia during treatment with atorvastatin [14] and simvastatin [15] . This interaction may be worse if you currently have any type of kidney problem.You healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Fibrates, in fact, can cause liver and kidney damage. Compare Fenofibrate vs Simvastatin head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. doctor or pharmacist) for more information.You may experience an increased risk of severe muscle pain, flu-like symptoms, and sudden decrease in the amount of urine.Contact your healthcare professionals (e.g. You need to report these side effects to your doctor right away, as well as address the risks that are posed by the simultaneous use of these drugs. These studies certainly emphasized a statement of statin-mediated up-regulation and activation of PPARα, which could be a target mediator of effects produced by both statins and fibrates (fenofibrate, gemfibrozil, etc.) having a history of muscle-related side effects when taking a statin or fibrate (another type of medicine for high cholesterol) having a family history of myopathy or rhabdomyolysis; If one or more of these apply to you, you may need to be frequently monitored to check for complications. doctor or pharmacist) as soon as possible about taking these two medicines together. However, monotherapy with either of these drugs does not always achieve lipid goals in the dyslipidaemic patient. Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. 17.Martin PD, Dane AL, Schneck DW, Warwick MJ. The combination of a statin and a fibrate may, how- Farnier M, Diabetes: statins, fibrates, or both?, Curr Atheroscler Rep, 2001;3:10. Fibrates have also been recommended as an adjunct to 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor (statin) therapy for patients unable to achieve LDL‐C and non‐HDL‐C goals. Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans. Among those prescribed a non-CYP3A4-metabolized statin, 40.0% of patients were concomitantly given an interacting drug, and approximately 20% of patients were concomitantly given a labeled inhibitor, predominantly calcium channel blockers, other statins, and fibrates. The additive effects of statin–fibrate combinations on lipid profiles have been documented. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. All rights reserved.Published content on this site is for information purposes and is not a substitute for professional medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Moderate. It is not affiliated with or is an agent of, the Oxford Heart Centre, the John Radcliffe Hospital or the Oxford University Hospitals NHS Foundation Trust group.Statin-Fibrate Combination for the Treatment of Dyslipidaemia Studies comparing lipid-lowering therapies have shown that while atorvastatin reduces all LDL subfractions, fenofibrate reduces LDL density.Recognising that statin and fibrate therapies affect different aspects of lipoprotein metabolism, combination therapy with these two classes of drug is emerging as a possible therapeutic approach for many high-risk patients, especially those with atherogenic dyslipidaemia. The management consisted in changing the medication to a different statin or a fibrate in 57% of cases, dosage reduction in 17% of cases, and definitive statin discontinuation in 20% of cases. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trialCopyright® 2020 Radcliffe Medical Media. This information is generalized and not intended as specific medical advice. HDL cholesterol is known as the “good” cholesterol and protects you from heart disease. Fibrates are also recommended as adjunct therapy for patients receiving statins whose low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol is not reduced to goal levels. Fenofibrate rated 5.8/10 vs Simvastatin rated … A fixed-dose tablet combining atorvastatin 40mg with low-dose fenofibrate 100mg (LCP-AtorFen) is currently in clinical development.An outcome trial with statin–fibrate therapy has yet to be completed.
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