Total testosterone comprises free testosterone (2–3%) and testosterone bound to either sex hormone–binding globulin (SHBG) (60–80%) or albumin (20–40%) (We have here analyzed the effect of statins on testosterone levels in a cross-sectional epidemiological study of men with type 2 diabetes. Posology. Unable to load your delegates due to an error We studied 857 men with T2DM screened from … One ampoule / vial of Nebido (corresponding to 1000 mg testosterone undecanoate) is injected every 10 to 14 weeks. Purpose To determine the impact of testosterone and testosterone replacement therapy (TRT ) on mortality and assess the independence of this effect by adjusting statistical models for statin and PDE 5I use. Methods. PDE5I use, included as a confounding factor, was associated with decreased mortality in all patients and, those not on TRT, suggesting independence of effect. Cox regression models were used to compare survival in the three testosterone level/treatment groups, the analysis adjusted for age, statin and PDE5I use, BMI, blood pressure and lipids.Compared with the Low T/untreated group, mortality in the Normal T/untreated (HR: 0.62, CI: 0.41–0.94) or Low T/treated (HR: 0.38, CI: 0.16–0.90) groups was significantly reduced. Limitations of this study are its observational nature and the resultant inability to prove causality. PDE5I use, included as a confounding factor, was associated with decreased mortality in all patients and, those not on TRT, suggesting independence of effect. 2015 Apr;16(5):625-8. doi: 10.1517/14656566.2015.1011124. most effective drugs ever created in terms of mortality. In other words, too high or too low is no bueno. Atorvastatin is a more potent statin than simvastatin, thus causing a greater reduction in the total cholesterol and hence total testosterone levels. 2013 Oct 21;169(6):725-33. doi: 10.1530/EJE-13-0321. Indeed, cholesterol and other lipid fraction levels were not significantly different between simvastatin- and atorvastatin-treated groups.In a normal physiological state, luteinizing hormone (LH) promotes uptake of cholesterol by the testis and stimulates testosterone synthesis. Low testosterone levels occur in over 40% of men with type 2 diabetes mellitus (T2DM) and have been associated with increased mortality. 10(3): 251–258. To determine the impact of testosterone and testosterone replacement therapy (TRT) on mortality and assess the independence of this effect by adjusting statistical models for statin and PDE5I use. Other measurements included blood pressure, A1C, nonfasting lipid levels, height, weight, and waist circumference. Those treated with atorvastatin had lower levels of total testosterone with a trend toward lower SHBG compared with untreated men, whereas those treated with simvastatin were not significantly affected. In men, a healthy testosterone level is the main player to help keep optimal cholesterol numbers and mitigate risk actors for cardiovascular disease like stroke and heart attack, but testosterone replacement therapy in the case of low testosterone may actually have the opposite effect (e.e. If you do not receive an email within 10 minutes, your email address may not be registered, 2015. Of 169 men treated with statins, 81 were treated with atorvastatin, 66 with simvastatin, 15 with pravastatin, and 7 with other statins (3 with fluvastatin, 1 with cerivastatin, and 3 with “unknown statin”). Register 2020 Jul;38(3):271-284. doi: 10.5534/wjmh.200027. Most of the subjects were recruited from the retinal screening program, which is attended by virtually all patients with diabetes in the Barnsley area. The study population comprised patients with diabetes usually managed in primary care facilities as well as secondary care patients.
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