It is recommended that the new dose should be reduced by 30-50% to allow for incomplete cross-tolerance. Medications involved in switch therapy include antibiotics, analgesics, antipsychotics, and antivirals.Equivalent Dose & Drug Conversions / Transfers / Switching Therefore, the table only contains the most commonly used antidepressants.The goal of this switching table is to offer a guide for physician and pharmacist in switching antipsychotics. Dosage range for ACE-Inhibitors3 Captopril 12.5 – 150mg daily (in 2 or 3 divided doses) Enalapril 2.5 – 40mg daily
ACE inhibitors and ARBs share indications, contraindications and most side effects (except cough, more frequent with ACE inhibtors). At least one of these exceptions must be documented in the patient record lieu of prescription, if they apply: Medical reason(s) for not prescribing ACE/ARB therapy
The table should be clear, easy to use and contain the most important information.
Chapter 19 Cardioprotective drugs. DOSING CLINICAL GUIDELINE AUGUST 2018 TABLE 1. Equivalent Dose & Drug Conversions / Transfers / SwitchingClinical Resource: Pharmaceutical Information Centre Publication
2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts).
ACE inhibitors are also used to treat left ventricular dysfunction and heart failure, to prevent strokes, and to prevent and treat kidney disease in people with hypertension or diabetes. If a patient develops an ACEI-induced cough, switch to an ARB.
This section features links to a wide range of clinical resources on equivalent doses and conversions for opioids, benzodiazepines, antidepressants, antipsychotics, corticosteroids and more. Angiotensin Receptor Antagonist Therapeutic InterchangeAlthough studies exist comparing different PPIs, and some may suggest superiority of one agent over another, current NICE guidance does not recommend any particular PPI.Of the five PPIs licensed for use in the UK (esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole), only lansoprazole and omeprazole are included on the NHSGGC Formulary. Calcium channel blockers (CCBs) and angiotensin-converting enzyme (ACE) inhibitors are used to treat high blood pressure.
While intravenous medications may be more bioavailable and have greater effects, some oral drugs produce serum levels comparable to those of the parenteral form. When choosing a PPI it should be noted that the licensed indications and the potential for interactions may differ between individual drugs.This article will briefly review the classification of HF according to current guidelines, the role of ARBs in HF, review the recommended dosing for ARBs, and discuss the major ARB HF Trials.This Q&A offers considered advice on how to safely convert patients from doxazosin XL to standard release doxazosin. OR. In the case of antipsychotic medications, this issue must be carefully addressed. As ARBs are more expensive and have not shown any additional clinical benefits over ACE inhibitors, they are usually considered as an alternative for ACE inhibitors intolerant patients.ACE inhibitors and ARBs share most indications and contraindications:De Sutter J, Mendes M, Franco OH. Eur Heart J 2016; 37: 2315–2381.De Lorenzo A. When indicated, they should be started at low dose and increased gradually to reach the target dose. -Usual dose: 2 to 4 mg/kg IV, divided and given every 6 to 8 hours OR as a continuous infusion-Maximum dose: 50 mg/dose 16 years and older: ORAL:-Treatment dose: 150 mg orally 2 times a day OR 300 mg orally once a day after the evening meal or at bedtime-Maintenance dose: 150 mg orally once a day at bedtime
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