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11, No. Epub 2016 Jun 29.Greco R, Barbanti MC, Lupo Stranghellini MT, Giglio F, Morelli M, Messina C, Forcina A, Oltolini C, Piemontese S, Scarpellini P, Marktel S, Assanelli A, Carrabba M, Vago L, Corti C, Bernardi M, Peccatori J, Ciceri F.Bone Marrow Transplant. This site needs JavaScript to work properly.
You can also search for this author in Aims. Atypon Inclusion criteria of the study were as follows: (1) at least six months after kidney transplant; (2) oral administration of study drugs, TAC (PrografThe study was conducted in compliance with the Declaration of Helsinki, the International Conference on Harmonization Guidelines for Good Clinical PracticeBlood samples were drawn pre-dose and post-dose 1, 2, 3, and 4 hours after taking TAC and MMF at the same time. Epub 2016 Apr 7.Meng HY, Li X, Jin WL, Yan CK, Dong XH, Xu Q, Peng YY, Li ZB, Li Y, Luo ZH, Xu LQ, Yang H.Eur J Clin Pharmacol. (2015). The effect of co-administered MMF and other clinical factors including the dose of TAC and genotypes (In this research, population pharmacokinetic model-based evaluation was used to simultaneously quantify the effect of DDI, genetic polymorphism, and other known clinical factors on the pharmacokinetics of TAC. Lindbom, L., Pihlgren, P. & Jonsson, E. N. PsN-Toolkit–a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Bottiger, Y., Brattstrom, C., Tyden, G., Sawe, J. Unable to load your delegates due to an error & Marquet, P. Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. TAC, tacrolimus; IIV in pharmacokinetic parameters was assumed for apparent clearance and volume of distribution of TAC and MPA. 12.Tacrolimus 75 13.Valganciclovir 86 14. Each population was generated with the combination of the dose of TAC (1 mg bid and 2 mg bid), the dose of MMF (500 mg bid and 1,000 mg bid), According to the final model and the simulation results, detailed dosing algorithm of TAC was developed. Please enable it to take advantage of the complete set of features! (Steady state concentrations of TAC were simulated in 32 virtual populations.
The immunosuppression dosing in conjunction with azole use at discharge was analyzed to develop a dosing algorithm dependent on whether fluconazole, posaconazole, or voriconazole was used. Model development procedure consisted of sequential steps of structure model building, explanation of the residual error, and identification of significant covariates. doi: 10.1093/cid/ciw326. 2011 Nov;21(11):713-20. doi: 10.1097/FPC.0b013e32834a48ca.Hesselink DA, Bouamar R, Elens L, van Schaik RH, van Gelder T.Clin Pharmacokinet.
2016, Rong, Y., Mayo, P., Ensom, M. H. H. & Kiang, T. K. L. Population Pharmacokinetic Analysis of Immediate-Release Oral Tacrolimus Co-administered with Mycophenolate Mofetil in Corticosteroid-Free Adult Kidney Transplant Recipients. Internet Explorer). We collected data from a cohort of 255 renal transplant recipients from a single centre. 2008 Aug;21(4):409-14. doi: 10.1097/QCO.0b013e328307c7d9.Jović Z, Janković SM, Ružić Zečević D, Milovanović D, Stefanović S, Folić M, Milovanović J, Kostić M.Eur J Drug Metab Pharmacokinet. & Kim, S. J. Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure. Bergmann, T. K., Hennig, S., Barraclough, K. A., Isbel, N. M. & Staatz, C. E. Population pharmacokinetics of tacrolimus in adult kidney transplant patients: impact of CYP3A5 genotype on starting dose.
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