Fertigarzneimittel sind zugelassen u. a. zur Verhinderung von Abstoßungsreaktionen nach Organtransplantation, bei Autoimmunkrankheiten sowie bei Psoriasis und atopischem Ekzem. Dieses verstoffwechselt auch zahlreiche andere Wirkstoffe. Management: Decrease the zanubrutinib dose to 80 mg once daily during coadministration with a strong CYP3A4 inhibitor. If combined, reduce lapatinib dose to 500 mg daily. No evening doses of ivacaftor (150 mg) alone should be administered.Eliglustat: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Eliglustat. Budesonide (Oral Inhalation): CYP3A4 Inhibitors (Strong) may increase the serum concentration of Budesonide (Oral Inhalation). Management: Consider reducing cyclosporine doses empirically by 50% to 80% during coadministration with ketoconazole or voriconazole, dose reductions with other azoles are also likely required. Management: Avoid concurrent use of pazopanib with strong inhibitors of CYP3A4 whenever possible. Evaluate renal function (particularly serum creatinine) at baseline and periodically during therapy.• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Management: Reduce the quetiapine dose to one-sixth of the regular dose when combined with strong CYP3A4 inhibitors.
Axitinib: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Axitinib. Benzhydrocodone: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Benzhydrocodone.
QT-prolonging Strong CYP3A4 Inhibitors (Moderate Risk) may increase the serum concentration of Ivosidenib. Fluconazole and isavuconazonium considerations are addressed in separate monographs. Monitor for prolonged QT intervalDeflazacort: CYP3A4 Inhibitors (Strong) may increase serum concentrations of the active metabolite(s) of Deflazacort.
In patients >14 years of age or 12 to 14 years and weighing >50 kg, data suggest that pharmacokinetics are similar to adults (Friberg 2012). The DUPIXENT "Instructions for Use" contains more detailed instructions on the preparation and administration of DUPIXENT [see INSTRUCTIONS FOR USE]. Simeprevir: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Simeprevir. Management: When combined with strong CYP3A4 inhibitors, administer two elexacaftor/tezacaftor/ivacaftor tablets (100 mg/50 mg/75 mg) in the morning, twice a week, approximately 3 to 4 days apart. Von der gesamten eingenommen Dosis erreicht etwa ein Viertel den großen Der Wirkstoff Tacrolimus ist zur Vorbeugung und Behandlung von Abstoßungsreaktionen nach einer Leber-, Nieren- oder Als Tacrolimus-Salbe wird der Wirkstoff zur Erhaltungstherapie oder zur Behandlung eines Ekzemschubs bei Patienten mit atopischem Ekzem (Die Anwendung von Tacrolimus erfolgt in der Regel langfristig bis lebenslang.
Prior to infusion, must dilute to ≤5 mg/mL with NS, LR, DPowder for oral suspension: Add 46 mL of water to the bottle to make 40 mg/mL suspension. DUPIXENT is a clear to slightly opalescent, colorless to pale yellow solution. DexAMETHasone (Systemic): May decrease the serum concentration of Voriconazole.Dexlansoprazole: CYP2C19 Inhibitors (Moderate) may increase the serum concentration of Dexlansoprazole. Sollte ein solcher Wechsel beabsichtigt sein, darf dieser nur unter ärztlicher Aufsicht mit engmaschigen Kontrollen des Tacrolimus-Blutspiegels erfolgen.Tacrolimus wird in der Leber über das Cytochrom-P450-3A4-Enzym abgebaut wird. Im Off-label-Use wird es bei weiteren Krankheitsbildern angewendet. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Recent Blog posts. ELIDEL Cream should not be used with occlusive dressings. Monitor for toxicities if combined.Alfentanil: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Alfentanil. Tacrolimus ist ein Immunsuppressivum aus der Gruppe der Calcineurin-Inhibitoren. Management: Consider alternatives to this drug combination. Management: Avoid use of lorlatinib with strong CYP3A4 inhibitors. Reconstituted solutions are stable for up to 24 hours under refrigeration at 2°C to 8°C (36°F to 46°F). Our staff has the experience you need to get your life on the path you want. Tazemetostat: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Tazemetostat. Irinotecan Products: CYP3A4 Inhibitors (Strong) may increase serum concentrations of the active metabolite(s) of Irinotecan Products. Monitor for increased alitretinoin effects/toxicities if combined with a strong CYP3A4 inhibitor.Almotriptan: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Almotriptan. Specifically, concentrations of the active monomethyl auristatin E (MMAE) component may be increased. Tacrolimus (Systemic): Voriconazole may increase the serum concentration of Tacrolimus (Systemic). Tacrolimus (Topical): Antifungal Agents (Azole Derivatives, Systemic) may … Management: Avoid use of ceritinib and strong CYP3A4 inhibitors that prolong the QTc interval whenever possible. Exposure to unconjugated MMAE, the cytotoxic small molecule component of polatuzumab vedotin, may be increased. Specifically, serum concentrations of SN-38 may be increased. Management: Limit the maximum vilazodone dose to 20 mg daily in patients receiving strong CYP3A4 inhibitors.
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