To present a case of tamoxifen retinopathy on a 57-year-old woman.A review of history, clinical
Bilateral retinal pigmented epithelium (RPE) function compromised was indicated by reduced Arden ratio in EOG.Tamoxifen-induced retinopathy could be detected by SD-OCT and EOG. She explained that they might have missed the early retinal changes if they had not checked the OCT scans. Recently, with developments of retinal imaging such as SD-OCT, more and more manifestations of tamoxifen retinopathy has been reported including cavitation in the macular (Doshi et al. But in this study, the researchers found a prevalence rate of 12%. A 57-year-old woman with metastatic breast carcinoma treated by surgery and high-dosage tamoxifen chemotherapy developed tamoxifen retinopathy characterized by white superficial retractile retinal lesions primarily in the paramacular area.
© 2020 BioMed Central Ltd unless otherwise stated. It had been found to reveal differences in patients with tamoxifen retinopathy, but it was not statistically significant, possibly owing to limited number of cases (Kuchenbecker et al. As it is irreversible, patients who are given tamoxifen need regular ophthalmic consultation, including SD-OCT and EOG before and during the treatment in order to early detect and avoid further retinal damage. Cataracts are painless, and they present with slow progressive vision loss. Tamoxifen retinopathy may be more of an issue than previously recognized, researchers in South Korea have found—and optical coherence tomography (OCT) may be needed to diagnose the earliest signs of the condition. TAMOXIFEN … (See "Cataract in adults" and 'Tamoxifen and toremifene' below.) As it is irreversible, patients who are given tamoxifen need regular ophthalmic consultation, including SD-OCT and EOG before and during the treatment in order to early detect and avoid further retinal damage.Tamoxifen is an oral estrogen antagonist drug, which is an adjuvant treatment of breast cancer when used in low doses (Early Breast Cancer Trialists’ Collaborative Group The current standard treatment with Tamoxifen for breast cancer is 5 consecutive years, however the global Adjuvant Tamoxifen: Longer against Shorter (ATLAS) trial has recently showed that 10 years of treatment reduced the risk of recurrence and mortality of breast cancer (Davies et al. 1.
LW prepared and wrote the manuscript.
Uncommonly, cataracts may be a long-term side effect of antiestrogenic drugs, such as tamoxifen and toremifene, as well as the alkylating agent busulfan. 2014). 2006). So it is highly probable that the patient’s retinopathy was blamed to tamoxifen. Spectral-domain Optical Coherence Tomography (SD-OCT), showed bilateral disruption of the ellipsoid zone and interdigitation zoneROG showed that the arden radio was compromised by 1.658 and 1.638 of the right and left eye, respectivelyThe patient had once received chemotherapy with paclitaxel and epirubin for 6 months and side effects of these drugs on retina should be considered.
Previous studies have found a prevalence rate of 1.5% to 11.8% in patients being treated for breast cancer. External examination and pupillary evaluation were normal. Current medications were levamlodipinebesylate, olmesartan, acarbose, Novolin 30R, probucol and simvastatin.On examination, her best-corrected visualacuity was 20/50 in the right eye and 20/80 in the left eye. Onco Targets Ther 7:1361–1366Nair AG, Das D, Goyal A, Gandhi RA (2012) The eyes have it!
Surv Ophthalmol 51(6):535–549Early Breast Cancer Trialists’ Collaborative Group (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
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