If you are switching from one medication to another in the same class, you can usually switch drugs immediately or start the new drug at a lower dose while slowly tapering off of the first drug.
If you notice mood changes with Zonegran, speak to your doctor or nurse.
You can ask your pharmacist or healthcare provider for information about Zonisamide Capsules that is written for health professionals.Inactive ingredients: colloidal silicon dioxide, microcrystalline cellulose, stearic acid and talc.The 25 mg capsule shell contains gelatin and titanium dioxide. Check with your doctor right away if you have a fever, dark urine, headache, rash, stomach pain, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, trouble breathing, unusual tiredness, or yellow eyes or skin. Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated. As with other AEDs, patients should contact their physician if they intend to become pregnant or are pregnant during zonisamide therapy. While it's safe to quit some things cold turkey, harder substances might … If metabolic acidosis develops and persists, consideration should be given to reducing the dose or discontinuing zonisamide (using dose tapering). Statistically significant treatment differences favoring Zonisamide Capsules were seen for doses of 100, 200, and 400 mg/day.In the second (n = 152) and third (n = 138) studies, patients had a 2 to 3 month baseline, then were randomly assigned to placebo or Zonisamide Capsules for three months. Zonisamide raised the threshold for generalized seizures in the kindled rat model and reduced the duration of cortical focal seizures induced by electrical stimulation of the visual cortex in cats. Many of these adverse reactions were dose-related (see Table 4 lists adverse reactions that occurred in at least 2% of patients treated with Zonisamide Capsules in controlled clinical trials that were numerically more common in the Zonisamide Capsules group. Cardiovascular defects were prominent in both rats and dogs. This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Tell your healthcare provider right away if you become pregnant while taking zonisamide.You and your healthcare provider should decide if you should take Zonisamide Capsules while you are pregnant.If you become pregnant while taking Zonisamide Capsules, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. A reduction in growth rate may eventually decrease the maximal height achieved. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one case of suicidal thinking or behavior for every 530 patients treated.
Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Chronic, untreated, metabolic acidosis may increase the risk for nephrolithiasis or nephrocalcinosis. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Incidences of skeletal malformations were also increased at the high dose, and fetal growth retardation and increased frequencies of skeletal variations were seen at all doses in this study.
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