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2007;24(4):811-15. combination of tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) or emtricitabine (FTC). The patient improved after discontinuing TDF and supportive management.Research off-campus without worrying about access issues. the site you are agreeing to our use of cookies. Epub 2014 Feb 6.AIDS. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Authors Anna Amjad Abbasi 1 , Ravikaran Patti 1 , Arindam Ghatak 2 , Chanaka Seneviratne 3 , Yizhak Kupfer 3 , Stephan … Background: Tenofovir, one of antiretroviral medication to treat human immunodeficiency virus (HIV) infection, is known to cause proximal renal tubular acidosis such as Fanconi syndrome, but cases of distal renal tubular acidosis had never been reported. One major concern regarding such widespread use of TDF is nephrotoxicity. A 20-year-old man with HIV infection developed nausea and vomiting without diarrhea after starting antiretroviral therapy. This site uses cookies. Laboratory investigations revealed non-anion gap metabolic acidosis, positive urine anion gap, hyperchloremia, and hypokalemia. Tenofovir, one of antiretroviral medication to treat human immunodeficiency virus (HIV) infection, is known to cause proximal renal tubular acidosis such as Fanconi syndrome, but cases of distal renal tubular acidosis had never been reported. Studies have shown that tenofovir leads to mitochondrial DNA depletion, especially affecting the mitochondria-rich PCT cells, and ultimately can cause renal cellular injury and development of Fanconi syndrome. To try to answer this question, host charac-teristics and drug pharmacokinetics must be considered. Clipboard, Search History, and several other advanced features are temporarily unavailable. Tenofovir Alafenamide-Induced Renal Tubular Acidosis . Markowitz M, Zolopa A, Squires K, Ruane P, Coakley D, Kearney B, Zhong L, Wulfsohn M, Miller MD, Lee WA.J Antimicrob Chemother. 2004;36(5):389-92. doi: 10.1080/00365540410027157. A 20-year-old man with HIV infection developed nausea and vomiting without diarrhea after starting antiretroviral therapy. Members of _ can log in with their society credentials belowRozhin Salimi, Ishmath Begum, Danturulu Muralidhar Varma, B Nandakrishna, Radhakrishnan Rajesh, and Sudha VidyasagarRozhin Salimi, Ishmath Begum, Danturulu Muralidhar Varma, B Nandakrishna, Radhakrishnan Rajesh, and Sudha VidyasagarMembers of _ can log in with their society credentials below This site uses cookies. Higher-than-expected rates of lactic acidosis among highly active antiretroviral therapy-treated women in Botswana: preliminary results from a large … The patient improved after discontinuing TDF and supportive management.Research off-campus without worrying about access issues. You can be signed in via any or all of the methods shown below at the same time.The email address and/or password entered does not match our records, please check and try again. Tenofovir Alafenamide-Induced Renal Tubular Acidosis. You can be signed in via any or all of the methods shown below at the same time.The email address and/or password entered does not match our records, please check and try again. Members of _ can log in with their society credentials belowRozhin Salimi, Ishmath Begum, Danturulu Muralidhar Varma, B Nandakrishna, Radhakrishnan Rajesh, and Sudha VidyasagarRozhin Salimi, Ishmath Begum, Danturulu Muralidhar Varma, B Nandakrishna, Radhakrishnan Rajesh, and Sudha VidyasagarMembers of _ can log in with their society credentials below Name must be less than 100 characters Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website.International Union against Sexually Transmitted InfectionsSuppression of HBV by tenofovir in HBV/HIV coinfected patients: a systematic review and meta-analysisTenofovir or zidovudine in three-drug combination therapy with one nucleoside reverse transcriptase inhibitor and one non-nucleoside reverse transcriptase inhibitor for initial treatment of HIV infection in antiretroviral-naive individualsCost-effectiveness of tenofovir as first-line antiretroviral therapy in IndiaRenal tubular dysfunction associated with tenofovir therapyEverything you need to know about distal renal tubular acidosis in autoimmune diseaseDistal renal tubular acidosis without renal impairment after use of tenofovir: a case reportA method for estimating the probability of adverse drug reactionsMolecular pathophysiology of renal tubular acidosisClinical utility of anion gap in deciphering acid–base disordersTenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention Simply select your manager software from the list below and click on download. New login is not successful because the max limit of logins for this user account has been reached.Login failed.
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