Patient is a UK registered trade mark.By using this site you agree to our use of cookies. Terbinafine tablets are used to treat infections caused by fungus that affect the fingernails or toenails.
Terbinafine tablets interfere selectively with fungal sterol biosynthesis at an early stageWhen given orally, the active substance concentrates in skin, hair and nails at levels associated with fungicidal activity. Thus, terbinafine may convert extensive CYP2D6 metabolisers (genotype) to poor metaboliser status (phenotype).Studies undertaken in vitro and in healthy volunteers suggest that terbinafine shows negligible potential to inhibit or induce the clearance of most drugs that are metabolized via other cytochrome P450 enzymes (e.g. Orally administered Terbinafine tablets are not effective against Pityriasis versicolor.
Recommended treatment for overdose consists of eliminating the active substance, primarily by the administration of activated charcoal, and giving symptomatic supportive therapy if required.
In the majority of liver failure cases the patients had serious underlying systemic conditions (see sections 4.3 and 4.8).Patients prescribed Terbinafine tablets should be instructed to report immediately any signs or symptoms suggestive of liver dysfunction such as pruritus, unexplained persistent nausea, decreased appetite, anorexia, jaundice, vomiting, fatigue, right upper abdominal pain, dark urine, or pale stools. They should preferably be taken at the same time each day and can be taken on an empty stomach or after a meal. Aetiology of any blood dyscrasias that occur in patients treated with Terbinafine tablets should be evaluated and consideration should be given for a possible change in medication regimen, including discontinuation of treatment with Terbinafine tablets.In patients with renal impairment (creatinine clearance less than 50 mL/min or serum creatinine of more than 300 micro mol/L) the use of Terbinafine tablets has not been adequately studied, and therefore, is not recommended (see section 5.2).Terbinafine tablets should be used with caution in patients with lupus erythematosus as very rare cases of lupus erythematosus have been reported.The plasma clearance of terbinafine may be accelerated by drugs which induce metabolism and may be inhibited by drugs which inhibit cytochrome P450. Terbinafine tablets in contrast to locally administered Terbinafine tablets treatment, has no effect in the treatment of Pityriasis (Tinea) versicolor.Following oral administration, terbinafine is well absorbed (>70%) and the absolute bioavailability of terbinafine from Terbinafine tablets as a result of first-pass metabolism is approximately 50%. For details see our Our clinical information is certified to meet NHS England's Information Standard.Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals.© Patient Platform Limited. Terbinafine is metabolised rapidly and extensively by at least seven CYP isoenzymes with major contributions from CYP2C9, CYP1A2, CYP3A4, CYP2C8 and CYP2C19. Terbinafine is prescribed to treat fungal nail or skin infections. The mechanism of tumour development has not been established. Registered in England and Wales.
In a two-year oral carcinogenicity study in rats, an increased incidence of liver tumours was observed in males at the highest dosage level of 69 mg/kg, at which systemic exposure was similar to clinical exposure.
Many fungal infections get better within 7 days of treatment with terbinafine – nail infections can take 3 months or more. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to doses of 130 (males) and 156 (females) mg/kg a day. In the treatment of toenail infections, 3 months is usually sufficient although a few patients may require treatment of 6 months or longer.
At low concentrations Terbinafine tablets is fungicidal against dermatophytes, moulds and certain dimorphic fungi. Terbinafine tablets is an allylamine which has a broad spectrum of antifungal activity. From the increase in plasma AUC an effective half-life of ~30 hours can be calculated. acute generalized exanthematous pustulosis (AGEP))Reporting suspected adverse reactions after authorisation of the medicinal product is important. The activity versus yeasts is fungicidal or fungistatic depending on the species. It allows continued monitoring of the benefit/risk balance of the medicinal product.
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