Manufacturer advises avoid or adjust dose—consult product literature. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Terbinafine is predicted to increase the exposure to eliglustat. Phenytoin: (Moderate) Caution is advised when administering terbinafine with phenytoin. Medscape - Onychomycosis dosing for Lamisil (terbinafine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. deutetrabenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, taking these drugs together may alter the systemic exposure of terbinafine. With itraconazole, the basis of some of the drug interaction is the inhibition/induction of CYP 450 3A4 isoform. ... All generic drug interactions for phenytoin oral (lists will include brand and generic names): 17 contraindicated drug interactions; Several warnings and contraindications have emerged related to drug interactions including recommendations to avoid coadministration of some macrolide antibiotics or azole antifungal agents with HMG-CoA reductase inhibitors (cholesterol-lowering agents), some benzodiazepines and some cardiac drugs, including digoxin (Lanoxin) and quinidine.1-9 Considering the widespread prevalence of superficial mycotic infections and associated oral antifungal use, it is rational to periodically revisit the subject of potential drug interactions and oral antifungal agents. The interactions between fluconazole and phenytoin, tolbutamide, and warfarin may be explained by the triazole-inhibiting CYP 2C9 isoform. Overall, as compared to other oral antifungal agents, terbinafine is associated with the most favorable safety profile with regard to clinically significant drug interactions.2-8,10 Through the use of illustrative case studies encountered in clinical practice, this article provides an overview and update on potential drug interactions related to the selection of specific oral antifungal agents.
The subject of drug-drug interactions has continued to expand in terms of understanding mechanisms, predicting potentially significant interactions based on advances in evaluating metabolic pathways and enhanced recognition of the importance of pharmacogenomics.1-3 Within dermatology, the clinical significance of drug interactions has been made evident by the withdrawal from the marketplace of the “nonsedating” antihistamines, terfenadine (Seldane) and astemizole (Hismanal), due to the increased propensity for prolongation of the QTc interval with subsequent ventricular arrhythmia when these agents were coadministered with erythromycin, ketoconazole (Nizoral) or itraconazole (Sporanox).3-8 This “hallmark interaction” is directly related to inhibition of the cytochrome (CYP) 3A4 metabolic pathway by several macrolide antibiotics and azole antifungal agents. Does Terbinafine Hcl Interact with other Medications? Fluconazole may inhibit both the CYP 450 3A4 and 2C9 isoforms. Between 1992 and 1997, although the number of approved drugs increased by two-fold, the number of associated drug interaction studies increased by slightly more than three-fold.
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