Acute pancreatitis (AP) is a heterogeneous disease ranging from a clinically mild form to a more severe forms associated with high morbidity and mortality (78).
Many classifications have been proposed.
Other causes include iatrogenic injury (i.e. Therefore, criteria to diagnose DIP should include the evidence for drug intake shortly preceding AP, an increased risk for AP in patients taking the drug, direct correlation between increased risk and dose, presence of a plausible biological mechanism, evidence in clinical trials using the specific drug and a re-challenge test. For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness. Other case reports about pancreatitis induced by lisinopril (13, 28, 42, 53), captopril (38), ramipril (41)and perindopril (27) have been also published.In one case-control study, the use of ACE inhibitor was associated with an increased risk of acute pancreatitis, with an odds ratio of 1.5.
Vemurafenib: an unusual UVA-induced photosensitivity. Silver EA, Silver AH, Silver DS, McCalmont TH. This is probably the reason why Tenner in a recent review raised the question about the real existence of DIP (82).A consequence of all these problems for the definition of DIP is its classification. Cutaneous toxicities of new treatments for melanoma.
Acute pancreatitis has been reported with both GLP-1 agonist (5, 44, 48, 75, 83) and DPP-4 inhibitor (30, 46).Over the last several years post-marketing reporting of this adverse events to FDA resulted in manufacturers emphasizing for acute pancreatitis and, later, in controindications for incretin-based therapies in patients with a history of pancreatitis (37).
The diagnosis of DIP remains possible or probable in many patients. Angiotensin II receptors regulate pancreatic secretion and microcirculation, and these effects may be contribute to the pathogenesis of ACE inhibitors induced pancreatitis (73).However, ACE inhibitors, in particular captopril, showed an important role in attenuating vascular permeability in experimental severe acute pancreatitis in rats, reducing expression of matrix metalloproteinase 9.
No human studies are available yet to confirm this experimental evidence and to develop a target therapy. Table 2.
Diseases & Conditions
Analysis of dermatologic events in vemurafenib-treated patients with melanoma.
Even if some authors have communicated that MP could safely be used after an AZA-induced episode of AP (1),most authors agree that a cross reaction after re- exposure of the related drug is probable.ACE inhibitors are one of the most commonly prescribed classes of medications, as they are used in hypertension, heart failure and proteinuria (32).
showed that metronidazole was associated to a threefold increased risk of acute pancreatitis (63).
Only a minority of cases associated with acute pancreatitis are linked to drugs and clinical presentation and mechanisms of injury to the pancreas are not well understood or controversial. However, a classification in definite, probable and possible association between drugs and pancreatitis is the most preferred (43, 61) A list of drugs classified in definitive and probable is listed on Since 1980, azathioprine (AZA) and its metabolite 6-mercaptopurine (6-MP) were reported to be able to induce pancreatitis (33). The knowledge of drugs commonly linked to acute pancreatitis © 2020 Collective work, copyright Regents of the University of Michigan.Supported by Health Information Technology & Services. Suchak R, Benson K, Swale V. Statin-induced Ro/SSa-positive subacute cutaneous lupus erythematosus. Patel AR, Turner ML, Baird K, et al.
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