Treat symptoms as follows:- Severe central anticholinergic effects (e.g. hallucinations, severe excitation): treat with physostigmine- Convulsions or pronounced excitation: treat with benzodiazepines- Respiratory insufficiency: treat with artificial respiration- Mydriasis: treat with pilocarpine eye drops and/or place patient in dark roomAn increase in QT interval was observed at a total daily dose of 8 mg immediate release tolterodine (twice the recommended daily dose of the immediate release formulation and equivalent to three times the peak exposure of the prolonged release capsule formulation) administered over four days. pyloric stenosisMultiple oral total daily doses of immediate release 4 mg (therapeutic) and 8 mg (supratherapeutic) tolterodine have been shown to prolong the QTc interval (see section 5.1). It allows continued monitoring of the benefit/risk balance of the medicinal product. Generic tolterodine cost $28,150, compared with $36,890; the price of darunavir, a cidofovir-class antiviral, came in between at $11,420 and $17,360. The effect of tolterodine on QT-prolongation was investigated further in 48 healthy male and female volunteers aged 18 – 55 years.
Subjects were administered 2 mg BID and 4 mg BID tolterodine as the immediate release formulations. To help you remember, use it at the same times each day. There is no data in mild to moderate renal impairment (see section 4.2 and 4.4).The exposure of the active moiety per mg dose is similar in adults and adolescents.
The effect of prokinetics like metoclopramide and cisapride may be decreased by tolterodine.Concomitant treatment with fluoxetine (a potent CYP2D6 inhibitor) does not result in a clinically significant interaction since tolterodine and its CYP2D6-dependent metabolite, 5-hydroxymethyl tolterodine are equipotent.Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel).A clinical study has indicated that tolterodine is not a metabolic inhibitor of CYP2D6, 2C19, 2C9, 3A4 or 1A2. Tolterodine is a competitive, specific muscarinic receptor antagonist with a selectivity for the urinary bladder over salivary glands in vivo. The 5-hydroxymethyl metabolite is pharmacologically active and equipotent with tolterodine. If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects. Because of the differences in the protein-binding characteristics of tolterodine and the 5-hydroxymethyl metabolite, the exposure (AUC) of unbound tolterodine in poor metabolisers is similar to the combined exposure of unbound tolterodine and the 5-hydroxymethyl metabolite in patients with CYP2D6 activity given the same dosage regimen. Do not double the dose to catch up.Store at room temperature away from light and moisture. (See section 4.8)There is no effect of food on the bioavailability of the capsules.The absolute bioavailability of tolterodine is 17 % in extensive metabolisers, the majority of the patients, and 65% in poor metabolisers (devoid of CYP2D6).
cardiomyopathy, myocardial ischaemia, arrhythmia, congestive heart failure)- Concomitant administration of drugs known to prolong QT-interval including Class IA (e. g. quinidine, procainamide) and Class III (e. g. amiodarone, sotalol) anti-arrhythmics.This especially holds true when taking potent CYP3A4 inhibitors (see section 5.1). Mestinon 60 mg Tablets - Summary of Product Characteristics (SmPC) by Mylan.
The clinical relevance of these findings is unclear and will depend on individual patient risk factors and susceptibilities present.Tolterodine should be used with caution in patients with risk factors for QT prolongation including:- Congenital or documented acquired QT prolongation- Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia- Relevant pre-existing cardiac diseases (i.e. Properly discard this product when it is expired or no longer needed. The mean exposure of the active moiety per mg dose is approximately two-fold higher in children between 5-10 years than in adults (See sections 4.2 and 5.1).In toxicity, genotoxicity, carcinogenicity and safety pharmacology studies no clinically relevant effects have been observed except those related to the pharmacological effect of the drug.Reproduction studies have been performed in mice and rabbits.In mice, there was no effect of tolterodine on fertility or reproductive function. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), Wolters Kluwer™ … The new data "should not be interpreted as a strong argument against generics," says Tom Frieden, head of the … (See section 5.1)Reporting suspected adverse reactions after authorisation of the medicinal product is important. The clinical effects of tolterodine on QT interval were studied in ECGs obtained from over 600 treated patients, including the elderly and patients with pre-existing cardiovascular disease. Dry eyes, abnormal vision (including abnormal accomodation)General disorders and administration site conditionsCases of aggravation of symptoms of dementia (e.g. Sugar spheres (containing sucrose and maize starch)Detrusitol XL prolonged-release capsules are packed in either blisters made of PVC/PVDC and aluminium foil with a heat seal coating of PVDC or HDPE bottles with LDPE closures.
Safeway Pharmacy Phone Number Brand Temovate, Gerd Pdf Abilify, Imipramine Uses Minomycin, Switching From Terazosin To Tamsulosin Bactrim, Prilosec OTC Walgreens Famvir, Doxepin For Psoriasis Lioresal, Pyriproxyfen Toxicity Cats Motilium, What To Do If I Catch A Cold During Chemo Super Force Jelly, Filariasis Symptoms Clomid, Arimidex And Claritin Cialis, Fighting Tamoxifen Fatigue Lotrisone, Banana Ice Cream Recipe Vitamix Zetia, Can Letrozole Raise Blood Sugar Elocon, Amitriptyline And Glaucoma, Lamictal Alcohol Reddit Diltiazem, Propranolol Er 80 Mg Prices, Modafinil For Bipolar Depression Eriacta, Neuhaus Winkels Vermox, Cenforce 200mg Maxolon, Griseofulvin Dosage Per Kg Motilium, Tenofovir Contraindications Kamagra Flavored, Is Orange Juice Good For Asthma Minocycline, Best Store-bought Ice Cream 2019 Finpecia, Alpha-gal Cure Feldene, How Long Can You Stay On Azathioprine Serophene, Is Ketoconazole Shampoo Safe Reddit Methotrexate, Aciphex Dosage Pamelor, Is Gabapentin A Maintenance Drug Lisinopril, Isoniazid: Synthesis Geodon, Mirtazapine Reddit Clarinex, Olmesartan Medoxomil-hctz 40-25 Mg Tablets Nolvadex, Aniracetam And Adderall Reddit Verapamil, Why Is Linezolid So Expensive Vantin, Alphagan Generic Prilosec, Ml96 Pill Compazine, Walmart Hair Regrowth Eriacta, Goodrx Clonidine Er, Diazepam And Grapefruit Juice High Aldactone, Hydrocortisone Acne Reddit Myambutol, Clindamycin Phosphate And Benzoyl Peroxide Gel Coreg, Keloid Miracle Cure Super Avana,