World Wide WoundsSystematic review of antimicrobial agents used for chronic woundsA systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetesSilver based wound dressings and topical agents for treating diabetic foot ulcersAre topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?© 2009 by the Infectious Diseases Society of America
Please enable it to take advantage of the complete set of features! Most topical antimicrobials can be divided into 1 of 2 major groups:Topical Antiseptic Products Available for Treating Chronic WoundsTopical Antiseptic Products Available for Treating Chronic WoundsAnother newly popular topical remedy for wound infections is honey. This site needs JavaScript to work properly.
Epub 2014 Apr 8.Heal CF, Buettner PG, Cruickshank R, Graham D, Browning S, Pendergast J, Drobetz H, Gluer R, Lisec C.BMJ.
Use of a newer, relatively nontoxic antiseptic (eg, cadexomer iodine or silver dressings) is preferable to use of topical antibiotics, especially agents that are available for systemic use.
World Wide WoundsMedical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonizationHoney and sugar as a dressing for wounds and ulcersThe sensitivity to honey of gram-positive cocci of clinical significance isolated from woundsEffects of pH-neutral, super-oxidised solution on human dermal fibroblasts in vitroClinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communicationInfections and diabetic foot syndrome in field practiceDermacyn on the infected foot ulcers of 10 patientsAntimicrobial peptides: potential use in skin infectionsMicrobiological profile of infected diabetic foot ulcersIn vitro antibacterial properties of pexiganan, an analog of magaininTopical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan creamTopical metronidazole for the treatment of wound odor: a review of the literatureColonization and infection with antibiotic-resistant bacteria in a long-term care facilityRetapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infectionsRetapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and childrenIn vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infectionsA review of the evidence for the use of topical antimicrobial agents in wound care. Major Potential Hazard, Moderate plausibility. 2018 Aug;22(8):573-587. doi: 10.1007/s10151-018-1814-1.
Treatment failure occurred in 12 of the 245 patients in the mupirocin group (4.9 percent) and in 11 of the 233 patients in the cephalexin group (4.7 percent). However, many other drugs also effectively cross the blood–brain barrier in the presence of meningitis and may be more effective and, perhaps most importantly, are bactericidal.Chloramphenicol may be indicated for anaerobic infections, prostatitis and salmonellosis.As chloramphenicol is usually bacteriostatic, it should not be used in immunocompromised patients or where bactericidal treatment is preferable.Avoid using chloramphenicol in cats with renal failure.Well distributed throughout the body, including CNS and eye.Attains higher concentrations in CSF than other antibacterials (30–50% of plasma concentrations in the absence of meningitis) and concentrations in CNS are maintained longer than in plasma.Eliminated primarily by hepatic glucuronide conjugation in the dog: only 5–10% is excreted unchanged in the urine.In the cat, more than 25% is excreted in the urine because of reduced ability to glucuronidate drugs.Elimination half-life is similar in both species: 4 h following IV administration, 7–8 h following PO administration.Drug from tablets and capsules is readily absorbed orally.Parenteral formulations are sodium succinate solution (which has an excellent bioavailability regardless of route) and aqueous suspension (gives lower plasma concentrations, maximum concentration 6 h after injection). Doona M, Walsh JB.
Topical chloramphenicol is an outmoded treatment. 7. (aureus, pseudintermedius) Pseudomonas spp. All anaerobic bacteria are inhibited by chloramphenicol at usual therapeutic concentrations.In small animals, chloramphenicol is often regarded now as the drug of first choice only for bacterial infection of the chambers of the eye.There is mixed opinion as to whether chloramphenicol is a drug of choice for bacterial CNS infections but it does achieve high levels in the CNS and has a very broad spectrum. It has a half-life of less than 5 h. The drug is well absorbed in cats after PO and IM administrations with a similar elimination half-life.
The wounds were examined after three to five days of therapy and again two to three days after completion of treatment.
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