All generic drug interactions for trazodone oral (lists will include brand and generic names): 24 contraindicated drug interactions; 62 serious drug interactions; 596 significant drug interactions; 239 minor drug interactions; UNABLE TO DISPLAY ANY INTERACTIONS AT THIS TIME. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined.Rasagiline: May enhance the serotonergic effect of Serotonergic Non-Opioid CNS Depressants. Consider the possibility of a fragility fracture if an antidepressant-treated patient presents with unexplained bone pain, point tenderness, swelling, or bruising (Rabenda 2013; Rizzoli 2012).• Ocular effects: May cause mild pupillary dilation, which can lead to an episode of narrow-angle glaucoma in susceptible individuals. This could result in serotonin syndrome. The study is based on trazodone hydrochloride and sulfamethoxazole; trimethoprim (the active ingredients of Trazodone hydrochloride and Bactrim ds, respectively), and Trazodone hydrochloride and Bactrim ds (the brand names). This could result in serotonin syndrome. Check for more interactions with the Drug Interaction Checker. This could result in serotonin syndrome.
Melanopsin Dependent Phototransduction is Impaired in Delayed Sleep-Wake Phase Disorder and Sighted Non-24-Hour Sleep-Wake Rhythm Disorder
Serotonergic Non-Opioid CNS Depressants may enhance the serotonergic effect of Serotonergic Opioids (High Risk).
Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) and CNS depression when these agents are combined.Trimeprazine: May enhance the CNS depressant effect of CNS Depressants.Warfarin: TraZODone may diminish the anticoagulant effect of Warfarin. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Psychological symptoms may also emerge such as agitation, anxiety, akathisia, panic attacks, irritability, aggressiveness, worsening of mood, dysphoria, mood lability, hyperactivity, mania/hypomania, depersonalization, decreased concentration, slowed thinking, confusion, and memory or concentration difficulties. Exceptions to this monograph are discussed in further detail in separate drug interaction monographs.Duvelisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Eletriptan: May enhance the serotonergic effect of Serotonergic Agents (High Risk). It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Management: Consider alternatives to this drug combination. Management: Consider dose reductions of droperidol or of other CNS agents (eg, opioids, barbiturates) with concomitant use. This could result in serotonin syndrome. All rights reserved. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined.Lemborexant: May enhance the CNS depressant effect of CNS Depressants. Trazodone is not FDA approved for use in pediatric patients. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined.Tetrahydrocannabinol: May enhance the CNS depressant effect of CNS Depressants.Tetrahydrocannabinol and Cannabidiol: May enhance the CNS depressant effect of CNS Depressants.Thalidomide: CNS Depressants may enhance the CNS depressant effect of Thalidomide. Management: Drugs listed as exceptions to this monograph are discussed in further detail in separate drug interaction monographs.Lorcaserin (Withdrawn From US Market): May enhance the serotonergic effect of Serotonergic Agents (High Risk).
Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined.Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).
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