Topamax was originally FDA-approved as a seizure medicine, also called an anticonvulsant.Topiramate is used to treat seizures in adults and children who are at least 2 years old. Acyclovir should be administered to a nursing mother with caution and only when indicated.Clinical studies of acyclovir did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. Ensuing renal tubular damage can produce acute renal failure.Abnormal renal function (decreased creatinine clearance) can occur as a result of acyclovir administration and depends on the state of the patient’s hydration, other treatments, and the rate of drug administration. Skip the missed dose if you are more than 6 hours late in taking it. Other drugs may interact with topiramate, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Topamax only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. You should not use To make sure Topamax is safe for you, tell your doctor if you have ever had:Topiramate can increase the level of acid in your blood (metabolic acidosis). Available for Android and iOS devices. Urinary excretion and renal clearance were correspondingly reduced.A multicenter trial of acyclovir injection at a dose of 250 mg/mIn placebo-controlled trials, 58 patients with initial genital herpes were treated with intravenous acyclovir 5 mg/kg or placebo (27 patients treated with acyclovir and 31 treated with placebo) every 8 hours for 5 days. Knowing and managing your triggers can help prevent cyclic vomiting syndrome, especially during the well phase. ADVERSE REACTIONS: Observed During Clinical PracticeADVERSE REACTIONS: Observed During Clinical PracticeCAUTION – RAPID OR BOLUS INTRAVENOUS INJECTION MUST BE AVOIDED (see WARNINGS and PRECAUTIONS).INTRAMUSCULAR OR SUBCUTANEOUS INJECTION MUST BE AVOIDED (see WARNINGS).Therapy should be initiated as early as possible following onset of signs and symptoms of herpes infections.Herpes Simplex Infections: Mucosal and Cutaneous Herpes Simplex (HSV-1 and HSV-2) Infections in lmmunocompromised PatientsAdults and Adolescents (12 years of age and older):Severe Initial Clinical Episodes of Herpes Genitalis:Adults and Adolescents (12 years of age and older):Adults and Adolescents (12 years of age and older):Neonatal Herpes Simplex Virus Infections (Birth to 3 months):Varicella Zoster Infections: Zoster in Immunocompromised Patients:Adults and Adolescents (12 years of age and older):We comply with the HONcode standard for trustworthy health information - An additional controlled study performed in Europe demonstrated similar findings.Two hundred and two infants with neonatal herpes simplex infections were randomized to receive either acyclovir 10 mg/kg every 8 hours (n = 107) or vidarabine 30 mg/kg/day (n = 95) for 10 days. The occurrence rate of birth defects approximates that found in the general population. Do not take extra medicine to make up the missed dose.Call your doctor for instructions if you miss two or more doses.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Avoid becoming overheated or dehydrated in hot weather. The pH has been adjusted with sodium hydroxide and if necessary, hydrochloric acid to fall in the range of 10.7 to 11.7. Adverse events that have been reported in association with overdosage include agitation, coma, seizures, and lethargy. Nausea and/or vomiting occurred in approximately 7% of the patients (the majority occurring in nonhospitalized patients who received 10 mg/kg).
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