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Call your doctor for medical advice about side effects.
Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating metabolite of sofosbuvir) is not; In vitro, slow metabolic turnover of velpatasvir … Many drugs can affect sofosbuvir and velpatasvir. Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 82 pounds (37 kilograms). https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZXBjbHVzYS1zb2Zvc2J1dmlyLXZlbHBhdGFzdmlyLTEwMDAwNzY=
/viewarticle/936795 Indicated for chronic hepatitis C virus (HCV) infection in adults with HCV genotypes 1, 2, 3, 4, 5, and 6 without cirrhosis or with compensated cirrhosis; or with decompensated cirrhosis for use in combination with ribavirin1 tablet (400 mg sofosbuvir/100 mg velpatasvir) PO qDayRefer to ribavirin prescribing information for dosage modificationsIndicated for chronic hepatitis C virus (HCV) infection in adults and children (≥6 years) or weighing at least 17 kg with HCV genotypes 1, 2, 3, 4, 5, and 6 without cirrhosis or with compensated cirrhosis; or with decompensated cirrhosis for use in combination with ribavirin<6 years or <17 kg: Safety and efficacy not establishedRefer to ribavirin prescribing information for dosage modificationsTest for evidence of current or prior hepatitis B virus (HBV) infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatmentCardiac disorders: Serious symptomatic bradycardia has been reported in patients taking amiodarone who initiated treatment with sofosbuvir in combination with another HCV direct-acting antiviralTest all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with HCV direct acting antivirals (DDAs)HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with DDAs and were not receiving HBV antiviral therapySome cases have resulted in fulminant hepatitis, hepatic failure, and deathMonitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-upInitiate appropriate patient management for HBV infection as clinically indicatedSofosbuvir/velpatasvir plus ribavirin combination regimen is contraindicated in patients for whom ribavirin is contraindicatedHepatitis B virus (HBV) reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV DDAs, and who were not receiving HBV antiviral therapy; HBV reactivation is characterized as an abrupt increase in HBV replication manifesting as a rapid increase in serum HBV DNA level (see Black Box Warnings and Dosing Considerations)If administered with ribavirin, warnings and precautions for ribavirin apply to this combination; see ribavirin prescribing informationContraindicated if administered with ribavirin in pregnant women and in men whose female partners are pregnantThere are no adequate data available to establish pregnancy risk for sofosbuvir or velpatasvirUnknown if sofosbuvir, velpatasvir, or their metabolites are distributed in human breast milkConsider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal conditionIf regimen includes ribavirin, refer to ribavirin prescribing informationA: Generally acceptable. We comply with the HONcode standard for trustworthy health information - SOFOSBUVIR; VELPATASVIR (soe fos' bue veer; vel pat' us veer) is an antiviral medicine.
The drug interactions described are based on studies conducted with either sofosbuvir and velpatasvir tablets (400 mg/100 mg), or sofosbuvir and velpatasvir as individual agents, or are predicted drug interactions that may occur with sofosbuvir and velpatasvir [see Warnings and Precautions (5.2, 5.3) and Clinical Pharmacology (12.3)].
Your list will be saved and can be edited at any time.The above information is provided for general 2002 Drugs that inhibit CYP2B6, CYP2C8, or CYP3A4 may increase plasma concentration of velpatasvir. Talk with your doctor about safe ways to prevent HCV transmission during sex.
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