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(PDF/35.38 KB) Venclyxto contains the active substance venetoclax. (PDF/934.69 KB)
In another study of 127 patients with or without 17p deletion or A third study in 389 patients with CLL who received at least one previous treatment showed that patients treated with Venclyxto plus rituximab lived longer without their disease getting worse (progression-free survival) than patients treated with rituximab and bendamustine (another cancer medicine).Another study involving 432 patients with CLL who had not previously been treated for the disease found that patients treated with Venclyxto plus obinutuzumab lived longer without their disease getting worse compared with patients treated with chlorambucil (a chemotherapy medicine) plus obinutuzumab.The most common side effects with Venclyxto used on its own (seen in more than 1 in 5 people) are low levels of neutrophils (a type of white blood cell), diarrhoea, nausea, anaemia (low red blood cell counts), nose and throat infection and tiredness. EMA is in the process of making appropriate changes to this website. 0000011530 00000 n
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(PDF/202.2 KB) Obinutuzumab and rituximab are immunotherapy medicines (medicines that act through the body’s defence system).Venclyxto should be started and supervised by a doctor with experience of cancer medicines and can only be obtained with a prescription. It is a lipophilic substance with very low solubility in water within the physiological pH range. 0000002740 00000 n
Venetoclax is a poorly soluble drug, BCS 4. +�:�a��ݚ(�f��3�Y�Q�l^h�eY�{�eW,�_>KJ | ��(�h;��TQ���� �1V}�:�j�'ϩr�R���(�dSM~�kBtY���%��Y�E桛9� (PDF/172.01 KB) Studies showed that patients with particular genetic mutations (17p deletion or The study in patients whose CLL had not been treated previously suggests that Venclyxto combined with obinutuzumab is a reasonable treatment option. It is used either in combination with other cancer medicines or on its own.Venclyxto can be used with obinutuzumab in patients who have not previously been treated for CLL or with rituximab in patients who have received at least one previous treatment. 0000010157 00000 n
(PDF/170.53 KB) Please note that orlistat capsules, 60 mg and 120 mg, are the subject of two separate reference products. (PDF/40.85 KB) The initial safety and side-effect profile of venetoclax–obinutuzumab had been established during a safety run-in phase.
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(PDF/101.62 KB) It is then continued at a dose of 400 mg daily, and the length of treatment depends on which medicine it is given with. (PDF/146.57 KB) The most common side effects are low levels of neutrophils, diarrhea, nausea, anemia, nose and throat infection and tiredness. (PDF/173.09 KB) Venetoclax attaches to a protein called Bcl-2.
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Ratios of predicted versus observed CThis article contains supplementary material available from the authors by request or via the Internet at We use cookies to help provide and enhance our service and tailor content and ads.
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