The inset graph in each panel shows the same curves on a larger scale. The primary difference between this drug and sitagliptin is that saxagliptin comes in 2 dose strengths, which are also adjusted based on the estimated GFR.Linagliptin is available in one dose strength; one size fits all in terms of renal function.
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During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. … The end of period 1 is defined by the day when the patient will receive a new vildagliptin medication pack§ because of HbA 1c ≥ 53 mmol/mol (7.0%) measured at two consecutive scheduled visits.
Sep 8, 2020 These drugs do not cause hypoglycemia and they do not cause weight gain; they have many good attributes.The first DPP4 inhibitor on the market was sitagliptin (Januvia®).
The population that we studied had well-managed cardiovascular and glycemic risk factors at baseline and was broadly similar to those studied in the SAVOR-TIMI 53 and EXAMINE trials.Our study has certain limitations. The opportunistic approach to data collection, apart from the selected values for glycated hemoglobin, resulted in limited acquisition of data regarding the ratio of urinary albumin to creatinine.Our study results showed that sitagliptin may be used in a diverse group of patients with type 2 diabetes who are at high cardiovascular risk without increasing rates of cardiovascular complications, but these results cannot exclude possible benefits or risks with longer durations of therapy or in patients with more complicated coexisting illnesses. In particular, I want to bring you up to date by discussing a new DPP4 inhibitor on the market, linagliptin (Tradjenta™).We have 3 agents in the DPP4 inhibitor class and these medications are similar in many ways. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. Please see our Comments on Medscape are moderated and should be professional in tone and on topic. Please confirm that you would like to log out of Medscape. This difference narrowed during the study period, with an overall least-squares mean difference of −0.29% in the sitagliptin group (95% confidence interval [CI], −0.32 to −0.27) (Shown are the rates of the primary cardiovascular outcome (a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina) (Panel A), the secondary cardiovascular outcome (a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) (Panel B), hospitalization for heart failure (Panel C), and death from any cause (Panel D) in the sitagliptin and placebo groups.
They are simple for patients to take, and they have few side effects.
Green and Bethel contributed equally to this article.This article was published on June 8, 2015, and updated on July 16, 2015, at NEJM.org.We thank the patients, without whom this study and these analyses would not have been possible; and the following academic partners and contract research organizations for their assistance: Parexel International, Jubilant Clinsys, Clinogent, Canadian VIGOUR Centre, Green Lane Coordinating Centre, and South Australian Health and Medical Research Institute.From the Duke Clinical Research Institute, Duke University School of Medicine, Durham (J.B.G., J.G., M.J.P., E.D.P.) §Participants in both arms will receive vildagliptin in a medication pack designed differently from the vildagliptin/placebo packs used in period 1. Hi.
The I bars indicate standard deviations.At 4 months, the mean glycated hemoglobin values were 0.4 percentage points lower in the sitagliptin group than in the placebo group.
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