pas dans l'évier ni dans la cuvette des cabinets) ni avec les ordures ménagères. Severity of interaction: Severe Evidence for interaction: Theoretical. When stopping treatment with citalopram the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of withdrawal reactions (see section 4.4 Special Warnings and Precautions for Use and section 4.8 Undesirable Effects). Select one or more newsletters to continue.
For information on concomitant treatment with non-selective, irreversible MAO-inhibitors see section 4.5. If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication..
Active ingredient. However, as with other SSRIs, the possibility of a pharmacodynamic interaction cannot be excluded. The fact that citalopram is metabolised by more than one CYP means that inhibition of its biotransformation is less likely as inhibition of one enzyme may be compensated by another. Should the patient enter a manic phase citalopram should be discontinued. There is no hypotension. Citalopram should not be used in the treatment of children and adolescents under the age of 18 years (see section 4.4).An initial dose of 10 mg daily for the first two weeks of treatment is recommended in patients with mild or moderate hepatic impairment. In chronic toxicity studies there were no findings of concern for the therapeutic use of citalopram. Cheplapharm Arzneimittel GmbH contact details. Citalopram Tablets are also indicated in the treatment of panic disorder with or without agoraphobia.Citalopram should be administered as a single oral dose of 20 mg daily. Experience with citalopram has not revealed any clinically relevant interactions with neuroleptics. Caution is recommended. Dosage should be restricted to the lower end of the dose range.Dosage adjustment is not necessary in cases of mild or moderate renal impairment. In a pharmacokinetic study no effect was demonstrated on either citalopram or imipramine levels,although the level of desipramine, the primary metabolite of imipramine was increased.
Formoterol is predicted to cause hypokalaemia (potentially increasing the risk of torsade de pointes) when given with citalopram. Unchanged citalopram is the predominant compound in plasma. However there have been reports of enhanced effects when SSRIs have been given with lithium or tryptophan and therefore the concomitant use of citalopram with these medicinal products should be undertaken with caution.
Especially elderly female patients seem to be at particularly high risk group. Citalopram did not reduce saliva flow in a single dose study in human volunteers and in none of the studies in healthy volunteers did citalopram have significant influence on cardiovascular parameters. However, the selectivity ratios of the metabolites are higher than those of many of the newer SSRIs. However, the combination of citalopram and alcohol is not advisable. Citalopram is contraindicated in the combination with linezolid unless there are facilities for close observation and monitoring of blood pressure (see section 4.5). Citalopram should not be given to patients receiving Monoamine Oxidase Inhibitors (MAOIs) including selegiline in daily doses exceeding 10 mg/day. Citalopram should not be used concomitantly with medicinal products with serotonergic effects such as sumatriptan or other triptans, tramadol, oxitriptan, and tryptophan.
Rhabdomyolysis is rare.Treatment should be symptomatic and supportive and include the maintenance of a clear airway and monitoring of ECG and vital signs until stable.Consider oral activated charcoal in adults and children who have ingested more than 5 mg/kg body weight within 1 hour.
When desipramine is combined with citalopram, an increase of the desipramine plasma concentration has been observed. SSRIs including citalopram may have an effect on pupil size resulting in mydriasis.
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