You can ask your pharmacist or healthcare provider for information about ZONEGRAN that is written for health professionals.This Medication Guide has been approved by the U.S. Food and Drug Administration.You are encouraged to report negative side effects of prescription drugs to the FDA. Safety and efficacy in pediatric patients below the age of 16 have not been established. The primary treatment to reverse symptoms is discontinuation of ZONEGRAN as rapidly as possible, according to the judgment of the treating physician. with known CYP3A4 inhibitors.Concomitant use of ZONEGRAN, a carbonic anhydrase inhibitor, with any other carbonic anhydrase Dosage of drugs is not considered in the study. -Titration: After 2 weeks at 100 mg/day, the dose may be increased to 200 mg/day as either a single or divided dose (100 mg orally 2 times a day) for at least 2 weeks; it can then be increased to 300 mg/day, then 400 mg/day either as a single daily dose or divided into 2 daily doses, with the dose stable for at least 2 weeks to achieve steady state at each level
or ZONEGRAN in one of two dose escalation regimens; either 1) 100 mg/day for five weeks, 200 The study is created by eHealthMe based on reports from FDA.The study is based on gender, age, active ingredients of any drugs used. generic drugs) are considered. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. inhibitor (e.g., topiramate, acetazolamide or dichlorphenamide), may increase the severity of metabolic combined) vs. placebo over weeks 8–12. The effect of zonisamide on growth and bone-related sequelae has not been systematically investigated.Measurement of baseline and periodic serum bicarbonate during treatment is recommended. Caution should be used when zonisamide is prescribed with other drugs that predispose patients to heat-related disorders; these drugs include, but are not limited to, carbonic anhydrase inhibitors and drugs with anticholinergic activity.The practitioner should be aware that the safety and effectiveness of zonisamide in pediatric patients have not been established, and that zonisamide is not approved for use in pediatric patients.Acute myopia and secondary angle closure glaucoma have been reported in patients receiving ZONEGRAN. If such signs or symptoms are present, the patient should be evaluated immediately. Behaviors of concern should be reported immediately to healthcare providers (see Some manifestations of acute or chronic metabolic acidosis include Chronic, untreated metabolic acidosis may result in Chronic, untreated metabolic acidosis in pediatric patients may reduce growth rates. Zonegran is a prescription medicine that is used with other medicines to treat partial seizures in adults.It is not known if Zonegran is safe or effective in children under 16 years of age.Zonegran may cause serious side effects, including:Call your health care provider right away if you have:These eye problems can lead to permanent loss of vision if not treated.Call your healthcare provider right away if you have any new eye symptoms, including any eye pain or redness or any new problems with your vision.Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:Side effects can happen at any time, but are more likely to happen during the first several weeks after starting Zonegran.These are not all of the possible side effects of Zonegran. Acute Single dose pharmacokinetic parameters are similar in elderly and young healthy volunteers (see Experience with ZONEGRAN daily doses over 800 mg/day is limited. Zonisamide was In placebo-controlled trials, 2.2% of patients discontinued ZONEGRAN or were hospitalized for depression compared to 0.4% of placebo patients. transient inward currents (T-type CaZonisamide is a carbonic anhydrase inhibitor.
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